Evidence map›Paper›PMID 24959982›Full record

ArticleVirology2014

The evolutionary dynamics of influenza A and B viruses in the tropical city of Managua, Nicaragua.

Martha I Nelson, Angel Balmaseda, Guillermina Kuan, Saira Saborio, Xudong Lin, Rebecca A Halpin, Timothy B Stockwell, David E Wentworth, Eva Harris, Aubree Gordon

Abstract read
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martha I NelsonFogarty International Center, National Institutes of Health, 16 Center Drive, Building 16, Room 202, Bethesda, MD 20892, USA. Electronic address: nelsonma@mail.nih.gov.
Angel BalmasedaLaboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua.
Guillermina KuanCentro de Salud Sócrates Flores Vivas, Ministry of Health, Managua, Nicaragua.
Saira SaborioLaboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua.
Xudong LinJ. Craig Venter Institute, Rockville, MD, USA.
Rebecca A HalpinJ. Craig Venter Institute, Rockville, MD, USA.
Timothy B StockwellJ. Craig Venter Institute, Rockville, MD, USA.
David E WentworthJ. Craig Venter Institute, Rockville, MD, USA.
Eva HarrisDivision of Infectious Diseases and Vaccinology, USA.
Aubree GordonDivision of Infectious Diseases and Vaccinology, USA; Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA. Electronic address: aubreegordon@berkeley.edu.

Funding

Epidemiology, transmission, and phylogenetics of influenza in a tropical countryU01AI088654 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI GORDON, AUBREE L, HARRIS, EVA · 2010 to 2014
$3.2M
Epidemiology and Transmission of Influenza in NicaraguaK02TW009483 · FIC · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GORDON, AUBREE L · 2012 to 2016
$419k
FIC NIH HHS K02 TW009483NIAID NIH HHS U01 AI088654NIAID NIH HHS U01AI088654
6 · The paper itself

Abstract

Despite mounting evidence of the high disease burden of influenza in tropical regions, relatively little viral sequence data is available from tropical countries in the Western hemisphere. To understand the evolutionary dynamics of influenza A and B viruses in Managua, Nicaragua, we performed a phylogenetic analysis of 1956 influenza viruses, including 335 collected for this study during 2007-2010 from a population-based cohort in Managua. North America was consistently identified as the most significant source of influenza virus diversity in Managua, although South America and Mexico were important viral sources during the 2009 A/H1N1 pandemic. The low number of viral introductions of Central American origin may reflect differences in the seasonality of influenza in Nicaragua versus neighboring countries, and underscores the need for additional data in this understudied region.

Indexed as

Evolution, MolecularGenetic VariationAdolescentChildChild, PreschoolCluster AnalysisCohort StudiesHumansInfluenza A virusInfluenza B virusInfluenza, HumanMaleMolecular EpidemiologyMolecular Sequence DataNicaraguaPhylogenyRNA, ViralCentral AmericaEvolutionInfluenzaMolecular epidemiology

Identifiers

PMID24959982
PMCPMC4175446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.