Evidence map›Paper›PMID 24959880›Full record

SynthesisPloS one2014

Vitamin B12 status in metformin treated patients: systematic review.

Qilin Liu, Sheyu Li, Heng Quan, Jianwei Li

Registry-linked trialOpen access · goldFull text readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05317806 (Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population), which is not on this map. Cited by 77 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 5 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05317806 phase4active not recruitingnot on this mapstarted 2022, after this paper: background citation

Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population

TypeinterventionalSponsorIndiana Hemophilia &Thrombosis Center, Inc.Ran2022 to 2027Enrolled15ConditionsPlasminogen Activator Inhibitor-1 Deficiency, Cardiac FibrosisArmsMetformin Extended Release Oral Tablet
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 170 citations in OpenAlex.

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  2. Metformin monotherapy for adults with type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2020 · on this map
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Qilin LiuDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Sheyu LiDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Heng QuanDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Jianwei LiDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRandomized controlled trials and observational studies have yielded inconsistent results on the effects of metformin on vitamin B12 reduction. We therefore performed a systematic review to analyze the effects of metformin on vitamin B12 concentration.

methodsPubMed, Medline, Embase, and the Cochrane central registry of controlled trials were searched to identify randomized controlled trials and observational studies exploring the association between metformin and vitamin B12 concentration in patients with type 2 diabetes mellitus or polycystic ovary syndrome. The main outcome measure was changes in serum vitamin B12 concentration after 6-208 weeks of treatment with metformin, as compared with placebo or other anti-hyperglycemic therapy.

resultsSix randomized controlled trials met the inclusion criteria. Serum vitamin B12 concentrations were significantly lower in patients treated with metformin than in those who received placebo or rosiglitazone (mean difference [MD], -53.93 pmol/L; 95% confidence interval [CI], -81.44 to -26.42 pmol/L, P = 0.0001). Subgroup analysis identified four trials in which patients received a lower dose of metformin (<2000 mg/d) and two in which they received a higher dose (≥2000 mg/d), with MDs in vitamin B12 concentration after metformin treatment of -37.99 pmol/L (95% CI, -57.44 to -18.54 pmol/L, P = 0.0001) and -78.62 pmol/L (95% CI, -106.37 to -50.86 pmol/L, P<0.00001), respectively.

conclusionsThe reduction of vitamin B12 may be induced by metformin in a dose dependent manner.

Indexed as

Diabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsMetforminPolycystic Ovary SyndromeRandomized Controlled Trials as TopicTreatment OutcomeVitamin B 12Hypoglycemic AgentsMetforminVitamin B 12

Identifiers

PMID24959880
PMCPMC4069007
OpenAlexW1971438651

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.