ArticlePloS one2014
Ionizing radiation selectively reduces skin regulatory T cells and alters immune function.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Radiotherapy-Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments.MedComm · 2026Review
- Protective Effects of Aqueous Extract of Myrtus communis L. Leaves against Oxidative Susceptibility of Rat Plasma and Hemoglobin during Exposure to X-ray Radiation.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Recent advances in understanding of radiation-induced skin tissue reactions with respect to acute tissue injury and late adverse effect.Journal of radiation research · 2025Review
- Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection.Radiation research · 2016Article
- Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model.Life sciences in space research · 2015Article
- Curcumin Stimulates the Antioxidant Mechanisms in Mouse Skin Exposed to Fractionated γ-Irradiation.Antioxidants (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin serves multiple functions that are critical for life. The protection from pathogens is achieved by a complicated interaction between aggressive effectors and controlling functions that limit damage. Inhomogeneous radiation with limited penetration is used in certain types of therapeutics and is experienced with exposure to solar particle events outside the protection of the Earth's magnetic field. This study explores the effect of ionizing radiation on skin immune function. We demonstrate that radiation, both homogeneous and inhomogeneous, induces inflammation with resultant specific loss of regulatory T cells from the skin. This results in a hyper-responsive state with increased delayed type hypersensitivity in vivo and CD4+ T cell proliferation in vitro. The effects of inhomogeneous radiation to the skin of astronauts or as part of a therapeutic approach could result in an unexpected enhancement in skin immune function. The effects of this need to be considered in the design of radiation therapy protocols and in the development of countermeasures for extended space travel.
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Registered trials
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