Evidence map›Paper›PMID 24959688›Full record

ArticleEmerging infectious diseases2014

Deaths attributable to carbapenem-resistant Enterobacteriaceae infections.

Matthew E Falagas, Giannoula S Tansarli, Drosos E Karageorgopoulos, Konstantinos Z Vardakas

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02709408 (Prospective Observational Study to Assess the Risk Factors, Clinical Management and Outcomes of Hospitalized Patients With Serious Infections Caused by Carbapenem-resistant Enterobacteriaceae and Acinetobacter Baumannii), which is not on this map. Cited by 286 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 6 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02709408 completednot on this mapstarted 2016, after this paper: background citation

Prospective Observational Study to Assess the Risk Factors, Clinical Management and Outcomes of Hospitalized Patients With Serious Infections Caused by Carbapenem-resistant Enterobacteriaceae and Acinetobacter Baumannii

Typeobservational_patient_registrySponsorFundación Pública Andaluza para la gestión de la Investigación en SevillaRan2016 to 2018Enrolled2,515ConditionsCarbapenem Resistant Bacteria Infection
3 · Its place in the literature

Who cites it

286 citing papers in PubMed, 6 syntheses or guidelines pooled it, 501 citations in OpenAlex.

  1. Pooled it
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  10. Clinical burden and outcomes of pediatric carbapenem-resistant Klebsiella pneumoniae bloodstream infections in a tertiary care center.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  11. Observational
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  14. Human Cases of Carbapenemase-Producing Escherichia coli Linked to Spread Between Animals and the Environment in a Veterinary Facility-Massachusetts, USA, 2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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  16. Observational
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226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Matthew E Falagas
Giannoula S Tansarli
Drosos E Karageorgopoulos
Konstantinos Z Vardakas
Tufts University · USAlfa Institute of Biomedical Sciences · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case-control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%-44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, -3% and -4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable.

Indexed as

Anti-Bacterial AgentsBacteremiaCarbapenemsCase-Control StudiesDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsHumansKlebsiella InfectionsKlebsiella pneumoniaeProspective StudiesRetrospective StudiesAnti-Bacterial AgentsCarbapenemsattributable deathsattributable mortalitybacteremiabacteriabloodstream infectioncarbapenemase-producingcarbapenemasescarbapenem resistancecarbapenem-resistant EnterobacteriaceaedeathsEnterobacteriaceaeinfectionsKlebsiella pneumoniaeKlebsiella pneumoniae carbapenemaseKPCmeta-analysismetaanalysismortalityoutcomesystematic review

Identifiers

PMID24959688
PMCPMC4073868
OpenAlexW1984903487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.