ArticleBioMed research international2014
Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Preventive effects ofBiomedical reports · 2026Article
- Preparation and evaluation of Dendrobium formosum extract-loaded microemulsions for anti-aging purpose.Scientific reports · 2025Article
- As a novel anticancer candidate, ether extract of Dendrobium nobile overstimulates cellular protein biosynthesis to induce cell stress and autophagy.Journal of applied biomedicine · 2023Article
- Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway.Bioscience reports · 2021Article
- Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract ofMolecules (Basel, Switzerland) · 2020Article
- Poly-(Lactic-co-Glycolic) Acid Nanoparticles for Synergistic Delivery of Epirubicin and Paclitaxel to Human Lung Cancer Cells.Molecules (Basel, Switzerland) · 2020Article
- Antiproliferative and apoptosis-inducing effect of common Tunisian date seed (var. Korkobbi and Arechti) phytochemical-rich methanolic extract.Environmental science and pollution research international · 2019Article
- Assessment of Antioxidant and Cytotoxic Activities of Extracts ofBiomolecules · 2019Article
- [Anti-tumor and immune-modulating effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Review
- The Combined Use ofFrontiers in pharmacology · 2017Article
- Acute toxicity and cytotoxicity evaluation ofLaboratory animal research · 2016Article
- Anticancer Activity of Garcinia morella on T-Cell Murine Lymphoma Via Apoptotic Induction.Frontiers in pharmacology · 2016Article
- Evaluation of chemical constituents and important mechanism of pharmacological biology in dendrobium plants.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice.Nutrition research and practice · 2014Article
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Authors and funding
2 authors.
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Abstract
Dendrobium, a genus of orchid, was found to possess useful therapeutic activities like anticancer, hypoglycaemic, antimicrobial, immunomodulatory, hepatoprotective, antioxidant, and neuroprotective activities. The study was aimed to evaluate the anticancer property of the ethanolic extract of Dendrobium formosum on Dalton's lymphoma. In vitro cytotoxicity was determined by MTT assay, apoptosis was determined by fluorescence microscopy, and cell cycle progression was analysed using flow cytometry; in vivo antitumor activity was performed in Dalton's lymphoma bearing mice. The IC50 value of ethanolic extract was obtained at 350 μg/mL in Dalton's lymphoma cells. Fluorescence microscopy analysis showed significant increase in apoptotic cell death in dose- and time-dependent manner which was further confirmed through the resulting DNA fragmentation. Further, flow cytometry analysis showed that the ethanolic extract arrests the cells in G2/M phase of the cell cycle. The in vivo anticancer activity study illustrates significant increase in the survival time of Dalton's lymphoma bearing mice on treatment with ethanolic extract when compared to control. These results substantiate the antitumor properties of ethanolic extract of Dendrobium formosum and suggest an alternative in treatment of cancer. Further studies are required regarding the isolation and characterization of bioactive components along with the analysis of molecular mechanism involved.
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