ArticleGastroenterology research and practice2014
Association between Helicobacter pylori Infection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review.
Article in Gastroenterology research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Relationship betweenBMJ open · 2019Pooled it
- Proton pump inhibitors' use and risk of hip fracture: a systematic review and meta-analysis.Rheumatology international · 2018Pooled it
- Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2016Pooled it
- Increased Risk of Osteoporosis in Patients With Peptic Ulcer Disease: A Nationwide Population-Based Study.Medicine · 2016Trial
- Bone Fragility in Gastrointestinal Disorders.International journal of molecular sciences · 2022Review
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- H. Pylori is related to osteoporosis but only in premenopausal female: a cross-sectional study.BMC musculoskeletal disorders · 2020Article
- The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced byDrug design, development and therapy · 2020Article
- Bone of Contention: Helicobacter pylori and Osteoporosis-Is There an Association?Digestive diseases and sciences · 2019Review
- Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study.BMC gastroenterology · 2018Article
- Correlation betweenGastroenterology research and practice · 2018Article
- Article
- The Associations Between Helicobacter pylori Infection, Serum Vitamin D, and Metabolic Syndrome: A Community-Based Study.Medicine · 2016Article
- Helicobacter pylori infection and osteoporosis in elderly patients.Caspian journal of internal medicine · 2015Article
- Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?Therapeutics and clinical risk management · 2015Article
- Proton pump inhibitors and risk of bone fractures.Current treatment options in gastroenterology · 2014Article
- Lifestyle Factors Rather Than Helicobacter pylori Infection or Estradiol Level are Associated With Osteopenia in Japanese Men.American journal of men's healthArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction. Helicobacter pylori (H. pylori) infection could lead to chronic local and systemic immune response. The resulting increase in proinflammatory cytokines could affect bone resorption and might increase the risk of osteoporosis. This study aimed to investigate the association between H. pylori infection and osteoporosis in elderly female patients with upper gastrointestinal diseases. Methods. A retrospective patient record review study was conducted in a regional teaching hospital in south Taiwan. Relevant information on female patients aged 65 and over who were diagnosed with diseases of esophagus, gastric ulcer, or duodenal ulcer during January 2008 to December 2010 were abstracted. Association between H. pylori infection and osteoporosis was evaluated using multivariate logistic regression analysis. Results. Of the 365 patients with a mean age of 77.3 years, 77 (21.1%) had H. pylori infection and 101 (27.7%) had been diagnosed with osteoporosis. Multivariate logistic regression analysis revealed that osteoporosis was significantly associated with H. pylori infection (adjusted odds ratio = 2.03, 95% confidence interval = 1.14-3.62) after adjusting for age group, body mass index group, and use of proton pump inhibitor. Conclusion. Osteoporosis was found to be associated with H. pylori infection in Taiwanese female patients with upper gastrointestinal diseases. Further studies with information on potential confounders are needed to confirm the association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.