ReviewFrontiers in microbiology2014
Learning from agriculture: understanding low-dose antimicrobials as drivers of resistome expansion.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed.
- Influence of housing system on antimicrobial resistance and population structure of extended-spectrum beta-lactamase-producing Escherichia coli in South Korean layer farms.Poultry science · 2026Article
- Review
- Inferred Mobility-Resolved Resistome Architecture Suggests Recurrent Co-Resistance Modules on a Conserved Chromosomal Backbone in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Integrated Phenotypic and Genomic Characterization of Cefotaxime/Clavulanic Acid Inhibitor-Positive Multidrug-ResistantAnimals : an open access journal from MDPI · 2026Article
- The First Review on Nano-Agricultural Applications of MXene and MBene-Based Materials for Plant-Immunoengineering, Controlled Protection, and Inducing Biostimulation Mechanisms.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Prophylactic efficacy of probiotics and their metabolites against Staphylococcus epidermidis.BMC microbiology · 2025Article
- A Review on the Degradation of Antibiotic Resistance Genes During Composting of Livestock Manure.Toxics · 2025Review
- Amoxicillin Resistance: An In Vivo Study on the Effects of an Approved Formulation on Antibiotic Resistance in Broiler Chickens.Animals : an open access journal from MDPI · 2025Article
- Expression of an antimicrobial peptide persulcatusin fused with calmodulin in rice cultured cells.Transgenic research · 2025Article
- Consumers' perspectives on antibiotic use and antibiotic resistance in food animals: a systematic review.NPJ science of food · 2025Article
- Antimicrobial use in animal farms in Egypt: rates, patterns, and determinants.The Journal of the Egyptian Public Health Association · 2025Article
- Antibiotic resistance and mitigation using One Health lens in aquaculture of Northern Nigeria.The Onderstepoort journal of veterinary research · 2024Article
- The impacts of animal agriculture on One Health-Bacterial zoonosis, antimicrobial resistance, and beyond.One health (Amsterdam, Netherlands) · 2024Review
- The effect of information provision on consumers' risk perceptions of, support for a ban, and behavioral intention towards the preventive use of antibiotics in food animals.BMC public health · 2024Article
- High carriage of plasmid-mediated quinolone resistance (PMQR) genes by ESBL-producing and fluoroquinolone-resistant Escherichia coli recovered from animal waste dumps.Molecular biology reports · 2024Article
- Antimicrobial resistance in the United States: Origins and future directions.Epidemiology and infection · 2024Review
- Article
- Electrochemical Biosensors for the Detection of Antibiotics in Milk: Recent Trends and Future Perspectives.Biosensors · 2023Review
- Nanobiotics and the One Health Approach: Boosting the Fight against Antimicrobial Resistance at the Nanoscale.Biomolecules · 2023Review
- Early-life prophylactic antibiotic treatment disturbs the stability of the gut microbiota and increases susceptibility to H9N2 AIV in chicks.Microbiome · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a growing public health challenge worldwide, with agricultural use of antimicrobials being one major contributor to the emergence and dissemination of antimicrobial resistance (AMR). Globally, most antimicrobials are used in industrial food animal production, a major context for microbiomes encountering low-doses or subtherapeutic-levels of antimicrobial agents from all mechanistic classes. This modern practice exerts broad eco-evolutionary effects on the gut microbiome of food animals, which is subsequently transferred to animal waste. This waste contains complex constituents that are challenging to treat, including AMR determinants and low-dose antimicrobials. Unconfined storage or land deposition of a large volume of animal waste causes its wide contact with the environment and drives the expansion of the environmental resistome through mobilome facilitated horizontal genet transfer. The expanded environmental resistome, which encompasses both natural constituents and anthropogenic inputs, can persist under multiple stressors from agriculture and may re-enter humans, thus posing a public health risk to humans. For these reasons, this review focuses on agricultural antimicrobial use as a laboratory for understanding low-dose antimicrobials as drivers of resistome expansion, briefly summarizes current knowledge on this topic, highlights the importance of research specifically on environmental microbial ecosystems considering AMR as environmental pollution, and calls attention to the needs for longitudinal studies at the systems level.
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