Evidence map›Paper›PMID 24959090›Full record

ArticleClinical and experimental gastroenterology2014

Increased fat in pancreas not associated with risk of pancreatitis post-endoscopic retrograde cholangiopancreatography.

Bhupesh Pokhrel, Eun Kwang Choi, Omer Khalid, Kumar Sandrasegaran, Evan L Fogel, Lee McHenry, Stuart Sherman, James Watkins, Gregory A Cote, Henry A Pitt and 3 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and experimental gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Bhupesh PokhrelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Eun Kwang ChoiDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Omer KhalidDepartment of Gastroenterology, St Louis University School of Medicine, St Louis, MO.
Kumar SandrasegaranDepartment of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Evan L FogelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Lee McHenryDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Stuart ShermanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
James WatkinsDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Gregory A CoteDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Henry A PittDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Nicholas J ZyromskiDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Beth JuliarDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Glen A LehmanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineUCLouvain Saint-Louis Brussels · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction. In this study, we aimed to determine if an increased quantity of pancreatic fat is an independent risk factor for pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP).

methodsIn this case control study, we retrospectively reviewed a local radiological and ERCP database to identify patients who had had abdominal magnetic resonance imaging (MRI) followed by ERCP no more than 60 days later between September 2003 and January 2011. Percentage of fat was determined by recording signal intensity in the in-phase (Sin) and out-of-phase (Sout) T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout)/(Sin) × 2 by an abdominal radiologist blinded to clinical history. Controls matched for age, gender, and other pancreatobiliary disease were selected from a group with no post-ERCP pancreatitis (before fat content of the pancreas was analyzed).

resultsForty-seven patients were enrolled. Compared with controls, subjects with post-ERCP pancreatitis were similar in terms of age (41.4 years versus 41.1 years), gender (21.2% versus 20.2% males), pancreatobiliary disease characteristics, and most ERCP techniques. Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.

conclusionIncreased pancreatic fat on MRI criteria is not an independent predictor of post-ERCP pancreatitis.

Indexed as

magnetic resonance imagingobesitypancreatic fatpost-ERCP pancreatitissphincter of Oddi dysfunction

Identifiers

PMID24959090
PMCPMC4061141
OpenAlexW2050896177

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.