ArticleJournal of the American Heart Association2014
Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Berbamine modulates pro-inflammatory cytokines and alleviates sepsis-induced acute myocardial injury in mice: role of NLRP3/GSDMD signaling axis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Physiological, molecular, and histological evaluation of the effects of cobalamin on cardiac function in castrated rabbits.Open veterinary journal · 2026Article
- Protective effects of allicin against stanozolol-induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model.Animal models and experimental medicine · 2025Article
- Negative Alterations in the Respiratory Activity of Isolated Crude Heart Mitochondria Following In Vivo Isoproterenol Injection in Rats Are Not Observed in Heart Homogenate Suggesting That the Isolation Procedure Generates Experimental Artefacts.International journal of molecular sciences · 2025Article
- Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling.Basic research in cardiology · 2024Article
- Takotsubo Syndrome and Gender Differences: Exploring Pathophysiological Mechanisms and Clinical Differences for a Personalized Approach in Patient Management.Journal of clinical medicine · 2024Review
- Perioperative management of Takotsubo cardiomyopathy: an overview.Journal of anesthesia, analgesia and critical care · 2024Review
- Development of a small animal model replicating core characteristics of takotsubo syndrome in humans.European heart journal open · 2024Article
- Liraglutide Protects Cardiomyocytes against Isoprenaline-Induced Apoptosis in Experimental Takotsubo Syndrome.Biomedicines · 2024Article
- Impact of Coronary Microvascular Dysfunction in Takotsubo Syndrome: Cause, Consequence or Both?Reviews in cardiovascular medicine · 2024Review
- Animal models of Takotsubo syndrome: bridging the gap to the human condition.Frontiers in cardiovascular medicine · 2024Review
- Inflammatory Forms of Cardiomyocyte Cell Death in the Rat Model of Isoprenaline-Induced Takotsubo Syndrome.Biomedicines · 2023Article
- Recurrent Myocardial Injury Leads to Disease Tolerance in a Murine Model of Stress-Induced Cardiomyopathy.JACC. Basic to translational science · 2023Article
- Acute stress induces long-term metabolic, functional, and structural remodeling of the heart.Nature communications · 2023Article
- Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice.Molecules (Basel, Switzerland) · 2023Article
- Refining the reproducibility of a murine model of stress-induced reversible cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2023Article
- The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023Review
- A Review of Cardiovascular Complications among Pregnant Patients with COVID-19.Reviews in cardiovascular medicine · 2022Review
- Histopathological Changes in the Liver, Heart and Kidneys Following Malayan Pit Viper (Toxins · 2022Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur objectives were to characterize functional and structural features of an experimental model of Takotsubo cardiomyopathy, and its response to beta-blockers. METHODS AND
resultsIn protocol 1, a dose-finding study: 69 rats received various doses of isoproterenol (ISO) and echocardiographic and histologic parameters were measured on days 2 to 3 or day 8. There were no dose-dependent effects and, out of 69 ISO-treated rats, 40 (58.0%) survived and 29 (42.0%) died within 24 hours. Of survivors, 30 had apical akinesis averaging 12.1 ± 1.6% of the long axis LV circumference. Out of the 40 survivors, 32.5% showed apical akinesis ≥ 10%, 42.5% showed akinesis<10% and 25% showed no apical akinesis. The basal portion of the LV was always preserved. At 24 hours, histology and ultrastructure showed necrosis, vacuolization, lipid droplets, mononuclear cell infiltration, damaged mitochondria, and edema. On day 8, apical akinesis fully resolved but histologic abnormalities were still present. In protocol 2, rats were randomized to Control; ISO100 mg/kg; propranolol+ISO; and metoprolol+ISO groups. Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage.
conclusionTC can be mimicked in a rat model of ISO exposure that demonstrates apical akinesis on days 2 to 3 with full recovery of systolic regional wall motion abnormality despite the presence of persistent foci of necrosis and fibrosis on day 8. Pretreatment with beta-blockers improved survival but did not affect structural and functional alterations.
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