ArticleJournal of medical screening2014
Test characteristics of faecal immunochemical tests (FIT) compared with optical colonoscopy.
Article in Journal of medical screening, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03264898 (Comparative Effectiveness of Fecal Immunochemical Tests With Optical Colonoscopy), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of Fecal Immunochemical Tests With Optical Colonoscopy (R01 CA215034)
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Guaiac-based faecal occult blood tests versus faecal immunochemical tests for colorectal cancer screening in average-risk individuals.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Guideline
- Free Fecal Immunochemical Test Disbursement in Eight Family Physician Offices.Journal of community health · 2015Trial
- Impact of antithrombotic therapy on colonoscopy outcomes in FIT-positive patients: implications for polyp detection, diverticulosis and normal findings.BMJ open gastroenterology · 2025Article
- Is Cognitive Impairment Associated with Inadequate Bowel Preparation for Colonoscopy?Journal of the American Board of Family Medicine : JABFM · 2025Article
- Colon lesions in elderly individuals with positive and negative fecal immunochemical test results among PERSIAN Guilan cohort study (PGCS) population.Caspian journal of internal medicine · 2025Article
- Comparative Performance of Common Fecal Immunochemical Tests : A Cross-Sectional Study.Annals of internal medicine · 2024Article
- Comparative effectiveness of five fecal immunochemical tests using colonoscopy as the gold standard: study protocol.Contemporary clinical trials · 2021Article
- A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening.PloS one · 2021Article
- Making FIT Count: Maximizing Appropriate Use of the Fecal Immunochemical Test for Colorectal Cancer Screening Programs.Journal of general internal medicine · 2020Article
- The First Screening Program for Colorectal Cancer in the North of Iran.Journal of gastrointestinal cancer · 2020Article
- Assessing adherence and cost-benefit of colorectal cancer screening for accountable providers.Proceedings (Baylor University. Medical Center) · 2019Article
- Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Article
- Which Fecal Immunochemical Test Should I Choose?Journal of primary care & community health · 2017Review
- Stool Based Testing for Colorectal Cancer: an Overview of Available Evidence.Current gastroenterology reports · 2017Review
- Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer.The American journal of gastroenterology · 2017Review
- Effect of Ambient Temperature Variations on Positivity of Manual Fecal Immunochemical Tests.Journal of primary care & community health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFaecal occult blood tests are often the initial test in population-based screening. We aimed to: 1) compare the results of single sample faecal immunochemical tests (FITs) with colonoscopy, and 2) calculate the sensitivity for proximal vs. distal adenomatous polyps or cancer.
methodsIndividuals scheduled for a colonoscopy were invited to complete a FIT prior to their colonoscopy preparation. FIT results were classified as positive, negative, or invalid. Colonoscopy reports were reviewed and abstracted. Because of product issues, four different FIT manufacturers were used. The test characteristics for each FIT manufacturer were calculated for advanced adenomatous polyps or cancer according to broad reason for colonoscopy (screening or surveillance/diagnostic).
resultsOf those invited, 1,026 individuals (43.9%) completed their colonoscopy and had a valid FIT result. The overall sensitivity of the FITs (95% confidence intervals) was 0.18 (0.10 to 0.28) and specificity was 0.90 (0.87 to 0.91) for advanced adenomas or cancer. The sensitivity for distal lesions was 0.23 (0.11 to 0.38) and for proximal lesions was 0.09 (0.02 to 0.25). The odds ratio of an individual with a distal advanced adenoma or cancer testing positive was 2.68 (1.20 to 5.99). The two individuals with colorectal cancer tested negative, as did one individual with high-grade dysplasia.
conclusionsThe sensitivity of a single-sample FIT for advanced adenomas or cancer was low. Individuals with distal adenomas had a higher odds of testing positive than those with proximal lesions or no lesions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.