ArticleInfection and immunity2014
Protective role of the capsule and impact of serotype 4 switching on Streptococcus mitis.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Encapsulation of Disease-Causing and Commensal Mitis Group Non-Pneumococcal Streptococci.Pathogens (Basel, Switzerland) · 2025Article
- Deciphering the Regulatory Role and Molecular Interactions That Drive the Competence Regulon Quorum Sensing Circuitry inBiochemistry · 2025Article
- Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases.Nature communications · 2024Article
- Investigating theMicrobiology (Reading, England) · 2022Article
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- Analyzing Macrophage Infection at the Organ Level.Methods in molecular biology (Clifton, N.J.) · 2022Article
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- The dental plaque biofilm matrix.Periodontology 2000 · 2021Review
- Effects of Expression ofFrontiers in microbiology · 2021Article
- Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China.Emerging infectious diseases · 2020Article
- Article
- Intranasal Immunization with the CommensalApplied and environmental microbiology · 2019Article
- PcsB Expression Diversity Influences onFrontiers in microbiology · 2019Article
- Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule.Scientific reports · 2018Article
- Molecular mechanisms driving Streptococcus mitis entry into human gingival fibroblasts in presence of chitlac-nAg and saliva.Journal of materials science. Materials in medicine · 2018Article
- A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.NPJ vaccines · 2018Article
- Sequencing of the variable region ofOpen biology · 2017Article
- Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens.PLoS pathogens · 2017Article
- Article
- Overcoming the Barrier of Low Efficiency during Genetic Transformation of Streptococcus mitis.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The polysaccharide capsule surrounding Streptococcus pneumoniae is essential for virulence. Recently, Streptococcus mitis, a human commensal and a close relative of S. pneumoniae, was also shown to have a capsule. In this study, the S. mitis type strain switched capsule by acquisition of the serotype 4 capsule locus of S. pneumoniae TIGR4, following induction of competence for natural transformation. Comparison of the wild type with the capsule-switching mutant and with a capsule deletion mutant showed that the capsule protected S. mitis against phagocytosis by RAW 264.7 macrophages. This effect was enhanced in the S. mitis strain expressing the S. pneumoniae capsule, which showed, in addition, increased resistance against early clearance in a mouse model of lung infection. Expression of both capsules also favored survival in human blood, and the effect was again more pronounced for the capsule-switching mutant. S. mitis survival in horse blood or in a mouse model of bacteremia was not significantly different between the wild type and the mutant strains. In all models, S. pneumoniae TIGR4 showed higher rates of survival than the S. mitis type strain or the capsule-switching mutant, except in the lung model, in which significant differences between S. pneumoniae TIGR4 and the capsule-switching mutant were not observed. Thus, we identified conditions that showed a protective function for the capsule in S. mitis. Under such conditions, S. mitis resistance to clearance could be enhanced by capsule switching to serotype 4, but it was enhanced to levels lower than those for the virulent strain S. pneumoniae TIGR4.
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