ArticleLaboratory animals2014
Manual versus automated blood sampling: impact of repeated blood sampling on stress parameters and behavior in male NMRI mice.
Article in Laboratory animals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
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- Male and female mice may respectively form stronger social aversive memories with same and different sex conspecifics.bioRxiv : the preprint server for biology · 2025Article
- A new external jugular venipuncture technique for efficient vascular access that exploits a murine anatomical variation.PloS one · 2025Article
- Heterotypic Stressors Unmask Behavioral Influences of PMAT Deficiency in Mice.International journal of molecular sciences · 2023Article
- Heterotypic stressors unmask behavioral influences of PMAT deficiency in mice.bioRxiv : the preprint server for biology · 2023Article
- Acclimation and Blood Sampling: Effects on Stress Markers in C57Bl/6J Mice.Animals : an open access journal from MDPI · 2023Article
- Non-invasive monitoring of microbiota and host metabolism using secondary electrospray ionization-mass spectrometry.Cell reports methods · 2023Article
- Article
- Biphasic Response of Astrocytic Brain-Derived Neurotrophic Factor Expression following Corticosterone Stimulation.Biomolecules · 2022Article
- Non-Invasive Sampling in the Aspect of African Swine Fever Detection-A Risk to Accurate Diagnosis.Viruses · 2022Article
- Improving the Quality of EDTA-treated Blood Specimens from Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- The Impact of Common Recovery Blood Sampling Methods, in Mice (Mus Musculus), on Well-Being and Sample Quality: A Systematic Review.Animals : an open access journal from MDPI · 2020Review
- Impact of three commonly used blood sampling techniques on the welfare of laboratory mice: Taking the animal's perspective.PloS one · 2020Article
- Clinical, Physiologic, and Behavioral Evaluation of Permanently Catheterized NMRI Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics.Animals : an open access journal from MDPI · 2019Article
- Control of (pre)-analytical aspects in immunoassay measurements of metabolic hormones in rodents.Endocrine connections · 2018Review
- Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats.Scientific reports · 2017Article
- Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice.Drug metabolism and disposition: the biological fate of chemicals · 2017Article
- Gene expression profiles and physiological data from mice fed resveratrol-enriched rice DJ526.Scientific data · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Facial vein (cheek blood) and caudal vein (tail blood) phlebotomy are two commonly used techniques for obtaining blood samples from laboratory mice, while automated blood sampling through a permanent catheter is a relatively new technique in mice. The present study compared physiological parameters, glucocorticoid dynamics as well as the behavior of mice sampled repeatedly for 24 h by cheek blood, tail blood or automated blood sampling from the carotid artery. Mice subjected to cheek blood sampling lost significantly more body weight, had elevated levels of plasma corticosterone, excreted more fecal corticosterone metabolites, and expressed more anxious behavior than did the mice of the other groups. Plasma corticosterone levels of mice subjected to tail blood sampling were also elevated, although less significantly. Mice subjected to automated blood sampling were less affected with regard to the parameters measured, and expressed less anxious behavior. We conclude that repeated blood sampling by automated blood sampling and from the tail vein is less stressful than cheek blood sampling. The choice between automated blood sampling and tail blood sampling should be based on the study requirements, the resources of the laboratory and skills of the staff.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.