Evidence map›Paper›PMID 24958435›Full record

ArticleJournal of autism and developmental disorders2014

Modeling the phenotypic architecture of autism symptoms from time of diagnosis to age 6.

Stelios Georgiades, Michael Boyle, Peter Szatmari, Steven Hanna, Eric Duku, Lonnie Zwaigenbaum, Susan Bryson, Eric Fombonne, Joanne Volden, Pat Mirenda and 8 more

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Trajectories of Autism Symptom Severity Change During Early Childhood.Journal of autism and developmental disorders · 2021
    Article
  8. Article
  9. Article
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  13. Maternal Serotonin Levels Are Associated With Cognitive Ability and Core Symptoms in Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018
    Article
  14. Article
  15. Article
  16. What will my child's future hold? phenotypes of intellectual development in 2-8-year-olds with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Stelios GeorgiadesOfford Centre for Child Studies, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada, georgis@mcmaster.ca.
Michael Boyle
Peter Szatmari
Steven Hanna
Eric Duku
Lonnie Zwaigenbaum
Susan Bryson
Eric Fombonne
Joanne Volden
Pat Mirenda
Isabel Smith
Wendy Roberts
Tracy Vaillancourt
Charlotte Waddell
Teresa Bennett
Mayada Elsabbagh
Ann Thompson
Pathways in ASD Study Team

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a "2-factor/3-class" model provided the best fit to the data. At Time 2, a "2-factor/2-class" model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the "2-factor/3-class" model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity.

Indexed as

PhenotypeAge FactorsChildChild Development Disorders, PervasiveChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMale

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.