ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2014
Intraobserver variability in fibroid size measurements: estimated effects on assessing fibroid growth.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Leiomyomata, neonatal anthropometry, and pregnancy outcomes in singleton pregnancies.Annals of epidemiology · 2023Trial
- Natural history of fibroids in pregnancy: National Institute of Child Health and Human Development Fetal Growth Studies - Singletons cohort.Fertility and sterility · 2022Trial
- Dairy Intake and Uterine Fibroid Development: A Prospective Study.Journal of women's health (2002) · 2026Article
- A prospective study of hair dyes and uterine leiomyomata incidence in the study of environment, lifestyle, and fibroids.Fertility and sterility · 2026Article
- Associations of per- and polyfluoroalkyl substances with uterine leiomyomata incidence and growth: a prospective ultrasound study.Journal of exposure science & environmental epidemiology · 2025Article
- Body Mass Index and Uterine Fibroid Development: A Prospective Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Combined oral contraceptive utilization and uterine fibroid incidence: A prospective study in a cohort of African-American women.PloS one · 2024Article
- Current status and challenges in uterine myometrial tissue engineering.Bioengineered · 2023Review
- Evaluation of the anatomical locations and sizes of uterine fibroids from ultrasound examination in Ghana.African health sciences · 2023Article
- Uterine artery embolization in Tanzania: a procedure with major public health implications.CVIR endovascular · 2023Article
- Sonographic Monitoring of Growth of Uterine Myomas in Untreated Women and Respective Influence Factors.Geburtshilfe und Frauenheilkunde · 2023Article
- Vitamin D and uterine fibroid growth, incidence, and loss: a prospective ultrasound study.Fertility and sterility · 2022Article
- Brominated flame retardants and organochlorine pesticides and incidence of uterine leiomyomata: A prospective ultrasound study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Intake of Lycopene and other Carotenoids and Incidence of Uterine Leiomyomata: A Prospective Ultrasound Study.Journal of the Academy of Nutrition and Dietetics · 2021Article
- Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study.American journal of epidemiology · 2020Article
- Uterine fibroid incidence and growth in an ultrasound-based, prospective study of young African Americans.American journal of obstetrics and gynecology · 2020Observational
- Comparison between bidirectional StratafixBMC women's health · 2020Article
- Natural History of Uterine Fibroids: A Radiological Perspective.Current obstetrics and gynecology reports · 2018Review
- Self-reported bacterial vaginosis and risk of ultrasound-diagnosed incident uterine fibroid cases in a prospective cohort study of young African American women.Annals of epidemiology · 2017Article
- Intramural myomas: to treat or not to treat.International journal of women's health · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate intraobserver variability of fibroid sonographic measurements and apply this factor to fibroid growth assessment.
methodsStudy participants were African American women aged 23 to 34 years who had never had a diagnosis of uterine fibroids. All participants underwent transvaginal sonography to screen for the presence of previously undiagnosed fibroids (≥0.5 cm in diameter). The diameters of up to 6 fibroids were measured in 3 perpendicular planes at 3 separate times during the examinations by experienced sonographers. Intraobserver variability as measured by the coefficient of variation (CV) for fibroid diameter and volume was calculated for each fibroid, and factors associated with the CV were assessed by regression models. The impact of variability on growth assessment was determined.
resultsNinety-six of 300 women screened were found to have at least 1 fibroid, yielding a total of 174 fibroids for this analysis. The mean CV for the 3 measurements of fibroid maximum diameter was 5.9%. The mean CV for fibroid volume was 12.7%. Fibroid size contributed significantly to intraobserver variability (P = .04), with greater variability for smaller fibroids. Fibroid type (submucosal, intramural, or subserosal) was not important. Fibroids from the same woman tended to have similar measurement variability when assessed for volume but not for maximum diameter. Calculations showed that when following up fibroids, as much as a 20% increase in diameter could be due to measurement error, not "true growth."
conclusionsA small fibroid must have a greater change in size than a large fibroid to conclude that it is growing, but even for small fibroids an increase in diameter of greater than 20% is likely to indicate true growth, not measurement variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.