ArticleMetabolites2014
Microextraction by Packed Sorbent (MEPS) and Solid-Phase Microextraction (SPME) as Sample Preparation Procedures for the Metabolomic Profiling of Urine.
Article in Metabolites, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Heat-stabilised rice bran consumption by colorectal cancer survivors modulates stool metabolite profiles and metabolic networks: a randomised controlled trial.The British journal of nutrition · 2017Trial
- Strategic approaches to assess and quantify the oxidative stress biomarkers in complex biological systems.Bioanalysis · 2025Review
- Recent Advances in Bioanalysis of Cephalosporins Toward Green Sample Preparation.Journal of separation science · 2025Review
- Automated microextraction by packed sorbent of endocrine disruptors in wastewater using a high-throughput robotic platform followed by liquid chromatography-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2023Article
- Article
- The Determination of Cannabinoids in Urine Samples Using Microextraction by Packed Sorbent and Gas Chromatography-Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Article
- Metabolic Profiling and Quantitative Analysis of Cerebrospinal Fluid Using Gas Chromatography-Mass Spectrometry: Current Methods and Future Perspectives.Molecules (Basel, Switzerland) · 2021Review
- [Research progress of microextraction by packed sorbent and its application in microvolume sample extraction].Se pu = Chinese journal of chromatography · 2021Article
- Solventless Microextration Techniques for Pharmaceutical Analysis: The Greener Solution.Frontiers in chemistry · 2021Review
- Thin Porous Poly(ionic liquid) Coatings for Enhanced Headspace Solid Phase Microextraction.Polymers · 2020Article
- Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review.Molecules (Basel, Switzerland) · 2020Review
- Green Approaches to Sample Preparation Based on Extraction Techniques.Molecules (Basel, Switzerland) · 2020Review
- Urinary volatile organic compounds in overweight compared to normal-weight children: results from the Italian I.Family cohort.Scientific reports · 2017Article
- From diagnosis to therapy in lung cancer: management of CT detected pulmonary nodules, a summary of the 2015 Chinese-German Lung Cancer Expert Panel.Translational lung cancer research · 2016Review
- Solid-phase microextraction technology forTrends in analytical chemistry : TRAC · 2016Article
- Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.Metabolites · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For a long time, sample preparation was unrecognized as a critical issue in the analytical methodology, thus limiting the performance that could be achieved. However, the improvement of microextraction techniques, particularly microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), completely modified this scenario by introducing unprecedented control over this process. Urine is a biological fluid that is very interesting for metabolomics studies, allowing human health and disease characterization in a minimally invasive form. In this manuscript, we will critically review the most relevant and promising works in this field, highlighting how the metabolomic profiling of urine can be an extremely valuable tool for the early diagnosis of highly prevalent diseases, such as cardiovascular, oncologic and neurodegenerative ones.
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Registered trials
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