ReviewClinical reviews in allergy & immunology2015
IgG4-associated cholangitis: a comprehensive review.
Review in Clinical reviews in allergy & immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- The ultrasound and contrast-enhanced ultrasound characteristics of IgG4-related cholangitis: compared with cholangiocarcinoma.Journal of ultrasound · 2026Article
- Diagnostic pitfalls in IgG4-related sclerosing cholangitis presenting as perihilar cholangiocarcinoma: case report with literature review.Frontiers in immunology · 2026Review
- Isolated IgG4-related sclerosing cholangitis mimicking hilar cholangiocarcinoma: A case report and review.Hepatology forum · 2025Article
- Case report: Isolated immunoglobulin G4-related sclerosing cholangitis misdiagnosed as hilar cholangiocarcinoma.Frontiers in oncology · 2024Article
- The NOD Mouse Beyond Autoimmune Diabetes.Frontiers in immunology · 2022Review
- Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough?Frontiers in immunology · 2022Review
- Blue-collar work is a risk factor for developing IgG4-related disease of the biliary tract and pancreas.JHEP reports : innovation in hepatology · 2021Article
- Immunoglobulin (Ig) G4-related sclerosing cholangitis in patients resected for presumed perihilar cholangiocarcinoma: a 10-year experience.Annals of translational medicine · 2021Article
- Isolated Type Immunoglobulin G4 Sclerosing Cholangitis: The Misdiagnosed Cholangiocarcinoma.Journal of clinical medicine research · 2021Review
- Diagnostic Approach to Suspected Perihilar Malignancy.Visceral medicine · 2021Review
- IgG4/IgG RNA ratio does not accurately discriminate IgG4-related disease from pancreatobiliary cancer.JHEP reports : innovation in hepatology · 2020Article
- IgG4-related disease with multiple organs involvement was effectively controlled by glucocorticoids: a case report.AME case reports · 2020Article
- IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis.Gut and liver · 2019Review
- Multivisceral IgG4-related disease presenting as recurrent massive gastrointestinal bleeding: a case report and literature review.BMC gastroenterology · 2018Review
- [IgG4-associated cholangitis - clinical presentation of an overlooked disease entity].Der Internist · 2018Review
- Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience.Langenbeck's archives of surgery · 2018Review
- The Immunologic Paradoxes of IgG4-Related Disease.Clinical reviews in allergy & immunology · 2018Review
- IgG4-related disease: a complex under-diagnosed clinical entity.Rheumatology international · 2018Review
- Article
- Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture.World journal of gastroenterology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG4-associated cholangitis (IAC) is a major manifestation of immunoglobulin G4-related disease (IgG4-RD), an inflammatory multiorgan disorder of unknown cause. IAC and autoimmune pancreatitis (AIP) may mimic sclerosing cholangitis, cholangiocarcinoma, or pancreatic carcinoma. Typically, elderly male patients present with abdominal discomfort, weight loss, jaundice, and itch. At present, no accurate diagnostic test for IAC and IgG4-RD is at hand, often causing significant diagnostic delay. Serum IgG4 is only diagnostic when markedly raised (>4× ULN). Imaging in IAC discloses mass-forming lesions and/or strictures in the biliary tract. Histology may show tissue infiltration of IgG4-expressing plasma cells. Diagnostic criteria for histologic and imaging findings, serum tests, organ manifestation pattern, and response to immunosuppressive therapy (HISORt) criteria are used for the diagnosis of IgG4-RD. Still, considering the difficulty in diagnosing IAC and AIP, unnecessary hepatic or pancreatic resections for presumed malignancies occur. The good response to corticosteroid therapy in IAC and other manifestations of IgG4-RD suggests an immune-mediated inflammatory disease. Maintenance immunosuppression after induction of remission is needed in the majority of patients to avoid relapse. The pathogenesis of IAC and IgG4-RD remains poorly understood. Unresolved questions include: (i) Does IgG4 have a pro- or anti-inflammatory role in IAC? (ii) Is IAC a B cell- and/or T cell-mediated disease? (iii) Which are the molecular targets attacked by the immune system in IgG4-RD? Here, we review the diagnostic and therapeutic management of the disease and discuss recent pathophysiological findings, which might help to better understand the molecular mechanisms contributing to IAC and other manifestations of IgG4-RD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.