Evidence map›Paper›PMID 24958311›Full record

ReviewNature reviews. Endocrinology2014

Hormonal and neural mechanisms of food reward, eating behaviour and obesity.

Susan Murray, Alastair Tulloch, Mark S Gold, Nicole M Avena

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Obesity Disrupts CtBP2-Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  19. Gut microbe-derivedProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susan MurrayNew York Obesity Research Center, Department of Medicine, Columbia University College of Physicians and Surgeons, P&S Box 30 DOM/NYORC, 630 West 168th Street, New York, NY 10032-3702, USA.
Alastair TullochNew York Obesity Research Center, Department of Medicine, Columbia University College of Physicians and Surgeons, P&S Box 30 DOM/NYORC, 630 West 168th Street, New York, NY 10032-3702, USA.
Mark S GoldDepartment of Psychiatry, College of Medicine, University of Florida, McKnight Brain Institute, 1149 SW Newell Drive, L4-100, Gainesville, FL 32610, USA.
Nicole M AvenaNew York Obesity Research Center, Department of Medicine, Columbia University College of Physicians and Surgeons, P&S Box 30 DOM/NYORC, 630 West 168th Street, New York, NY 10032-3702, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With rising rates of obesity, research continues to explore the contributions of homeostatic and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the existing information on select biological mechanisms associated with reward-related food intake, dealing primarily with consumption of highly palatable foods. In addition to their established functions in normal feeding, three primary peripheral hormones (leptin, ghrelin and insulin) play important parts in food reward. Studies in laboratory animals and humans also show relationships between hyperphagia or obesity and neural pathways involved in reward. These findings have prompted questions regarding the possibility of addictive-like aspects in food consumption. Further exploration of this topic may help to explain aberrant eating patterns, such as binge eating, and provide insight into the current rates of overweight and obesity.

Indexed as

EatingRewardAdultAnimalsBehavior, AddictiveBrainBulimiaDopamineFeeding BehaviorFemaleGhrelinHomeostasisHumansInsulinLeptinMaleDopamineGhrelinInsulinLeptinReceptors, Dopamine

Identifiers

PMID24958311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.