Evidence map›Paper›PMID 24958272›Full record

ReviewCritical reviews in oncology/hematology2014

Adrenocortical carcinoma: the management of metastatic disease.

André P Fay, Aymen Elfiky, Gabriela H Teló, Rana R McKay, Marina Kaymakcalan, Paul L Nguyen, Anand Vaidya, Daniel T Ruan, Joaquim Bellmunt, Toni K Choueiri

Abstract readReview
In one paragraph

Review in Critical reviews in oncology/hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Primary adrenal angiosarcoma: a rare case presentation.Journal of surgical case reports · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Management of adrenocortical carcinoma: are we making progress?Therapeutic advances in medical oncology · 2021
    Review
  19. Review
  20. American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

André P FayDana-Farber Cancer Institute, Boston, MA, United States. Electronic address: Andre_Fay@dfci.harvard.edu.
Aymen ElfikyDana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Gabriela H TelóJoslin Diabetes Center, Boston, MA, United States.
Rana R McKayDana-Farber Cancer Institute, Boston, MA, United States.
Marina KaymakcalanDana-Farber Cancer Institute, Boston, MA, United States.
Paul L NguyenDana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Anand VaidyaBrigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Daniel T RuanDana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Joaquim BellmuntDana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, MA, United States; Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address: toni_choueiri@dfci.harvard.edu.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USDana-Farber Brigham Cancer Center · USJoslin Diabetes Center · US

Funding

Physician Scientist Training in Cancer ResearchT32CA009172 · NCI · DANA-FARBER CANCER INSTITUTE · PI Jennifer R Brown, James A. DeCaprio · 1985 to 2026
$17.1M
NCI NIH HHS T32 CA009172
6 · The paper itself

Abstract

Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaAnimalsAntineoplastic Agents, HormonalDisease ManagementHumansAntineoplastic Agents, HormonalAdrenocortical carcinomaMetastatic diseaseTargeted therapiesTherapeutics

Identifiers

PMID24958272
PMCPMC4578298
OpenAlexW2071988003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.