ArticleMetabolites2013
Studies of Secondary Melanoma on C57BL/6J Mouse Liver Using 1H NMR Metabolomics.
Article in Metabolites, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
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- Enantiomeric Excess Bupivacaine in a Lavender Oil NLC Tested in a Melanoma Model: Prolonged Release and Anticancer Effect.Molecular pharmaceutics · 2025Article
- Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis inMetabolites · 2023Article
- Skin Cancer Diagnosis Based on Neutrosophic Features with a Deep Neural Network.Sensors (Basel, Switzerland) · 2022Article
- One extraction tool forJournal of pharmaceutical analysis · 2021Article
- Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts.Cancers · 2021Article
- Article
- The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin.Antioxidants (Basel, Switzerland) · 2020Review
- Melanoma Diagnosis Using Deep Learning and Fuzzy Logic.Diagnostics (Basel, Switzerland) · 2020Article
- Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Skin Lesion Segmentation in Dermoscopic Images with Combination of YOLO and GrabCut Algorithm.Diagnostics (Basel, Switzerland) · 2019Article
- Assessment of MR-based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T.Magnetic resonance in medicine · 2018Article
- Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling.Scientific reports · 2017Article
- Proton NMR characterization of intact primary and metastatic melanoma cells in 2D & 3D cultures.Biological research · 2017Article
- NMR metabolic fingerprints of murine melanocyte and melanoma cell lines: application to biomarker discovery.Scientific reports · 2017Article
- Article
- Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy.Metabolomics : open accessArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
NMR metabolomics, consisting of solid state high resolution magic angle spinning (HR-MAS) 1H-NMR, liquid state high resolution 1H-NMR, and principal components analysis (PCA) has been used to study secondary metastatic B16-F10 melanoma in C57BL/6J mouse liver. The melanoma group can be differentiated from its control group by PCA analysis of the estimates of absolute concentrations from liquid state 1H-NMR spectra on liver tissue extracts or by the estimates of absolute peak intensities of metabolites from 1H HR-MAS-NMR data on intact liver tissues. In particular, we found that the estimates of absolute concentrations of glutamate, creatine, fumarate and cholesterol are elevated in the melanoma group as compared to controls, while the estimates of absolute concentrations of succinate, glycine, glucose, and the family of linear lipids including long chain fatty acids, total choline and acyl glycerol are decreased. The ratio of glycerophosphocholine (GPC) to phosphocholine (PCho) is increased by about 1.5 fold in the melanoma group, while the estimate of absolute concentration of total choline is actually lower in melanoma mice. These results suggest the following picture in secondary melanoma metastasis: Linear lipid levels are decreased by beta oxidation in the melanoma group, which contributes to an increase in the synthesis of cholesterol, and also provides an energy source input for TCA cycle. These findings suggest a link between lipid oxidation, the TCA cycle and the hypoxia-inducible factors (HIF) signal pathway in tumor metastases. Thus, this study indicates that the metabolic profile derived from NMR analysis can provide a valuable bio-signature of malignancy and cell hypoxia in metastatic melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.