ArticleNature communications2014
Injectable bioadhesive hydrogels with innate antibacterial properties.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 348 citations in OpenAlex.
- Bio-Inspired Adhesive Hydrogels for Localized Therapeutic Delivery: From Catechol Chemistry to Smart Biointerfaces.Biomimetics (Basel, Switzerland) · 2026Review
- Structure-Function Regulation of Proteolytically Stable Amphiphilic Peptide-Based Soft Materials With Antimicrobial Efficacy Against Drug-Resistant Strains and Anticancer Activity in Triple-Negative Breast Cancer Cells.Chembiochem : a European journal of chemical biology · 2026Article
- Self-Healing and pH-Robust Hydrogels Enabled by Synergistic Supramolecular Interactions for Injectable Gastrointestinal Wound Repair.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms.Journal of nanobiotechnology · 2025Review
- Biomimetic 3D-Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Advances in cold atmospheric plasma therapy for cancer.Bioactive materials · 2025Review
- Fabrication of N-halamine coatings with long-lasting bacterial inhibition and bacterial biofilm disruption functions for invisible aligner applications.Materials today. Bio · 2025Article
- A Bio-Adaptive Janus-Adhesive Dressing with Dynamic Lubrication Overlayer for Prevention of Postoperative Infection and Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nasal In-Situ Gels of BrijAAPS PharmSciTech · 2025Article
- Applications of Hydrogels in Emergency Therapy.Gels (Basel, Switzerland) · 2025Review
- Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications.npj biomedical innovations · 2025Article
- A Multi-Responsive Hydrogel Combined With Mild Heat Stimulation Promotes Diabetic Wound Healing by Regulating Inflammatory and Enhancing Angiogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Hydrogel-Based Skin Regeneration.International journal of molecular sciences · 2024Review
- An Erythrocyte-Templated Iron Single-Atom Nanozyme for Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Near-Infrared Light-Triggered NO Nanogenerator for Gas-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy to Eliminate Biofilms.International journal of nanomedicine · 2024Article
- A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- Multifunctional Oxidized Dextran-Metformin as a Tissue-Adhesive Hydrogel to Prevent Postoperative Peritoneal Adhesions in Patients with Metabolic Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing.Bioactive materials · 2023Article
- Structural and biological engineering of 3D hydrogels for wound healing.Bioactive materials · 2023Review
- Photo-crosslinking hydrogel for wound healing in a pilonidal sinus patient after open surgery.Journal of surgical case reports · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adhesives kill both Gram-negative and Gram-positive bacteria, while sparing human erythrocytes. An optimal composition of 2.5 wt% oxidized dextran and 6.9 wt% polyethylenimine sets within seconds forming a mechanically rigid (~1,700 Pa) gel offering a maximum adhesive stress of ~2.8 kPa. A murine infection model showed that the adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the bioadhesive's surface, with minimal inflammatory response. The adhesive was also effective in a cecal ligation and puncture model, preventing sepsis and significantly improving survival. These bioadhesives represent novel, inherently antibacterial materials for wound-filling applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.