ArticleCellular and molecular life sciences : CMLS2015
Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.
Article in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- RGS proteins: Potential regulators of mouse melanopsin's signaling phototransduction cascade across ipRGC subtypes.Biophysical journal · 2026Article
- An Optimized Ex Vivo Protocol for Quantitative Electrophysiological Assessment of Neuromuscular Junctions and Skeletal Muscle Function Using the Aurora System.Bio-protocol · 2025Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- A systematic comparison of optogenetic approaches to visual restoration.Molecular therapy. Methods & clinical development · 2022Article
- Functional Differentiation of BMP7 Genes in Zebrafish:Frontiers in cell and developmental biology · 2022Article
- Melanopsin phototransduction: beyond canonical cascades.The Journal of experimental biology · 2021Review
- Chimeric human opsins as optogenetic light sensitisers.The Journal of experimental biology · 2021Article
- Circadian Photoentrainment in Mice and Humans.Biology · 2020Review
- Article
- Functional characterisation of naturally occurring mutations in human melanopsin.Cellular and molecular life sciences : CMLS · 2018Article
- Differential roles for cryptochromes in the mammalian retinal clock.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Phototransduction in Retinal Ganglion Cells.The Yale journal of biology and medicine · 2018Review
- Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.Current biology : CB · 2017Article
- Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina.Scientific reports · 2017Article
- In vitro transdifferentiation of human peripheral blood mononuclear cells to photoreceptor-like cells.Biology open · 2016Article
- Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells.Eye (London, England) · 2016Review
- Retinal Attachment Instability Is Diversified among Mammalian Melanopsins.The Journal of biological chemistry · 2015Article
- Isoforms of Melanopsin Mediate Different Behavioral Responses to Light.Current biology : CB · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Melanopsin expressing photosensitive retinal ganglion cells (pRGCs) represent a third class of ocular photoreceptors and mediate a range of non-image forming responses to light. Melanopsin is a G protein coupled receptor (GPCR) and existing data suggest that it employs a membrane bound signalling cascade involving Gnaq/11 type G proteins. However, to date the precise identity of the Gα subunits involved in melanopsin phototransduction remains poorly defined. Here we show that Gnaq, Gna11 and Gna14 are highly co-expressed in pRGCs of the mouse retina. Furthermore, using RNAi based gene silencing we show that melanopsin can signal via Gnaq, Gna11 or Gna14 in vitro, and demonstrate that multiple members of the Gnaq/11 subfamily, including Gna14 and at least Gnaq or Gna11, can participate in melanopsin phototransduction in vivo and contribute to the pupillary light responses of mice lacking rod and cone photoreceptors. This diversity of G protein interactions suggests additional complexity in the melanopsin phototransduction cascade and may provide a basis for generating the diversity of light responses observed from pRGC subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.