ArticleMetabolites2012
A historical overview of natural products in drug discovery.
Article in Metabolites, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 588 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
588 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Phytotherapy for acute respiratory tract infections in children: a systematically conducted, comprehensive review.Frontiers in pediatrics · 2025Pooled it
- Pooled it
- Neotropical palms: from their conservation to economic potential.Frontiers in plant science · 2024Pooled it
- Artificial intelligence-driven advancements in agricultural biotechnology.Journal, genetic engineering & biotechnology · 2026Review
- Article
- Crocetin Halts Tumorigenesis in Metastatic Breast Cancer via Disrupting CYP2J2/EET Axis.ACS omega · 2026Article
- Amazonian Bioactives in Biopolymer-Based Systems for Biomedical Applications: Current Advances and Future Perspectives.Materials (Basel, Switzerland) · 2026Review
- Bioprospecting Plant-Derived Natural Products: Integrating Chemical Diversity, Efficacy, Safety, and Technological Development.Plants (Basel, Switzerland) · 2026Article
- A novel synergistic phycobiliprotein combination against HIV-1 shows potent antiviral activity.AMB Express · 2026Article
- Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway.Cell biochemistry and function · 2026Article
- Computational investigation for exploring botanical ingredients as potential negative allosteric modulators targeting metabotropic glutamate receptor 5.Research in pharmaceutical sciences · 2026Article
- Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights.Journal of cellular and molecular medicine · 2026Review
- Species Extinction, Biodiversity, Human Health, and Inevitable Role of Lifestyle Medicine: A Narrative Review.American journal of lifestyle medicine · 2026Review
- Optimizing Extraction and HPLC-ESI-QTOF-MS/MS Analysis of Bound Phenolics From Okra (Food science & nutrition · 2026Article
- Chemical composition and antioxidant properties of selected mangrove species from the Sine Saloum Delta (Senegal) using UHPLC-MS/MS and molecular networking.Scientific reports · 2026Article
- Natural Product-Derived Ianthelliformisamines Inhibit Protein Translation and Block Bacterial Flagellum Assembly.ACS chemical biology · 2026Article
- The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development.Biology · 2026Review
- Article
- Bioactive metabolites from marine fungal sources: evaluation of antimicrobial and cytotoxic activities.BMC microbiology · 2026Article
- Secondary Metabolites Isolated from the GenusMarine drugs · 2026Review
528 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.