Observational studyDevelopmental medicine and child neurology2014
Functional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy.
Observational study in Developmental medicine and child neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Long-term outcomes of survivors of neonatal insults: A systematic review and meta-analysis.PloS one · 2020Pooled it
- How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy?Pediatric research · 2023Trial
- Medicaid unbroken: ensuring continuous United States public health insurance coverage for children to school age.Pediatric research · 2024Article
- Perceived family impact and coping mechanisms of caregivers of children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2023Article
- Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.Seminars in perinatology · 2022Review
- Outcome prediction in newborn infants: Past, present, and future.Seminars in perinatology · 2022Review
- Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages.Frontiers in pediatrics · 2022Article
- Bone morphogenetic protein signaling: a promising target for white matter protection in perinatal brain injury.Neural regeneration research · 2018Article
- Therapeutic Hypothermia: How Can We Optimize This Therapy to Further Improve Outcomes?Clinics in perinatology · 2018Review
- Parent Experience of Neonatal Encephalopathy.Journal of child neurology · 2017Article
- Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE).Seminars in perinatology · 2016Review
- Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.Seminars in perinatology · 2016Review
- An Evaluation of Cerebral and Systemic Predictors of 18-Month Outcomes for Neonates With Hypoxic Ischemic Encephalopathy.Journal of child neurology · 2015Article
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11 authors at 5 institutions in 1 country.
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Abstract
aimIn children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined the association between 18-month functional status by parental report and disability at 6-7 years.
methodProspective observational study involving participants in the NICHD randomized controlled trial of hypothermia for HIE. Parent questionnaires-Functional Status-II (FS-II), Impact on Family (IOF) and Family Resource Scale (FRS) at 18 months were correlated with 6- to 7-year developmental assessments. Disability at 6-7 years was defined as IQ < 70, gross motor functional classification scale level III-V, bilateral blindness, deafness, or epilepsy.
resultsRates of severe HIE (32 vs. 15%), public insurance (73% vs. 47%) and IOF scales were higher and mean (SD) FS-II independence (I) {54 (SD 35) vs. 98 (SD 8)} and general health (GH) {87 (SD 14) vs. 98 (SD 6)} scores were significantly lower in children with disability (n=37) at 6-7 years, compared to those (n=74) without disability. FS-II I scores were significantly associated with disability (OR 0.92; 95% CI 0.87-0.97; p=0.003). On path analysis, severe HIE, greater IOF and public insurance were associated with poorer 18-month FS-II I scores, which, in turn, were associated with disability at 6 to 7 years.
interpretationPoor independent functioning by parental report at 18 months in children with HIE was associated with childhood disability.
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