ArticleMetabolites2012
Comparative Chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357).
Article in Metabolites, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- Dual-functionality of Nocardiopsis alba B57 in biocontrol and plant growth: a metabolomic approach to agricultural sustainability.NPJ biofilms and microbiomes · 2025Article
- Genome diversity, population structure and MALDI-TOF MS profiling of Aspergillus oryzae/flavus strains from fermentation and wild environments.BMC genomics · 2025Article
- Divergent volatile metabolomes and flavor attributes in rice fermented byFrontiers in fungal biology · 2025Article
- Aspergillus Species from the Sabkha Marsh: Potential Antimicrobial and Anticancer Agents Revealed Through Molecular and Pharmacological Analysis.Biologics : targets & therapy · 2024Article
- Article
- Chromolaena laevigata (Asteraceae) as a source of endophytic non-aflatoxigenic Aspergillus flavus: chemical profile in different culture conditions and biological applications.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Updates on the Functions and Molecular Mechanisms of the Genes Involved inJournal of fungi (Basel, Switzerland) · 2021Review
- Medical Application of Substances Derived from Non-Pathogenic FungiJournal of fungi (Basel, Switzerland) · 2021Review
- Mass Spectrometry-Based Network Analysis Reveals New Insights Into the Chemodiversity of 28 Species inFrontiers in fungal biology · 2021Article
- Review
- A Liquid Chromatographic Method for Rapid and Sensitive Analysis of Aflatoxins in Laboratory Fungal Cultures.Toxins · 2020Article
- Predominant Mycotoxins, Pathogenesis, Control Measures, and Detection Methods in Fermented Pastes.Toxins · 2020Review
- A Polyphasic Approach to Compare the Genomic Profiles of Aflatoxigenic and Non-Aflatoxigenic Isolates ofToxins · 2020Article
- Article
- Taxonomy ofStudies in mycology · 2019Article
- The Issue of Misidentification of Kojic Acid with Flufuran inMolecules (Basel, Switzerland) · 2019Article
- Biofilm mediated synergistic degradation of hexadecane by a naturally formed community comprising Aspergillus flavus complex and Bacillus cereus group.BMC microbiology · 2019Article
- Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications.Applied microbiology and biotechnology · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus oryzae and A. flavus are important species in industrial biotechnology and food safety and have been some of the first aspergilli to be fully genome sequenced. Bioinformatic analysis has revealed 99.5% gene homology between the two species pointing towards a large coherence in the secondary metabolite production. In this study we report on the first comparison of secondary metabolite production between the full genome sequenced strains of A. oryzae (RIB40) and A. flavus (NRRL 3357). Surprisingly, the overall chemical profiles of the two strains were mostly very different across 15 growth conditions. Contrary to previous studies we found the aflatrem precursor 13-desoxypaxilline to be a major metabolite from A. oryzae under certain growth conditions. For the first time, we additionally report A. oryzae to produce parasiticolide A and two new analogues hereof, along with four new alkaloids related to the A. flavus metabolites ditryptophenalines and miyakamides. Generally the secondary metabolite capability of A. oryzae presents several novel end products likely to result from the domestication process from A. flavus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.