ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2014
Deep brain stimulation for the treatment of epilepsy: circuits, targets, and trials.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Treatment of epilepsy for people with Alzheimer's disease.The Cochrane database of systematic reviews · 2021Pooled it
- Treatment of epilepsy for people with Alzheimer's disease.The Cochrane database of systematic reviews · 2018Pooled it
- Treatment of epilepsy for people with Alzheimer's disease.The Cochrane database of systematic reviews · 2016Pooled it
- Clinical Trials Examining Deep Brain Stimulation for the Treatment of Epilepsy: An Analysis of the Current State.Cureus · 2025Review
- Absence seizures: Update on signaling mechanisms and networks.Epilepsia open · 2025Article
- Dataset of long-term multi-site LFP activity with spontaneous chronic seizures in temporal lobe epilepsy rats.Scientific data · 2025Article
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- A High-Frequency Temporal-Interference Alternative Current Stimulation Device Using Pulse Amplitude Modulation with Push-Pull Current Sources.Bioengineering (Basel, Switzerland) · 2025Article
- A Comprehensive Review of Recent Trends in Surgical Approaches for Epilepsy Management.Cureus · 2024Review
- The role of neuromodulation in the management of drug-resistant epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Adaptive fuzzy iterative learning control based neurostimulation system and in-silico evaluation.Cognitive neurodynamics · 2024Article
- A pediatrician's guide to epilepsy surgery.Current problems in pediatric and adolescent health care · 2024Article
- Article
- Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research.Cellular and molecular neurobiology · 2024Review
- Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads.Frontiers in neurology · 2024Article
- Novel Surgical Approaches in Childhood Epilepsy: Laser, Brain Stimulation, and Focused Ultrasound.Advances and technical standards in neurosurgery · 2024Article
- Neuromodulation Techniques in Children with Super-Refractory Status Epilepticus.Brain sciences · 2023Review
- A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management.Brain sciences · 2023Review
- The intralaminar thalamus: a review of its role as a target in functional neurosurgery.Brain communications · 2023Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.