ArticleBMC musculoskeletal disorders2014
Risk factors for knee replacement due to primary osteoarthritis, a population based, prospective cohort study of 315,495 individuals.
Article in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Men and Women's Occupational Activities and the Risk of Developing Osteoarthritis of the Knee, Hip, or Hands: A Systematic Review and Recommendations for Future Research.Arthritis care & research · 2020Pooled it
- The gut microbiome's role in the development and progression of post-traumatic osteoarthritis: A systematic review.Osteoarthritis and cartilage open · 2026Review
- Metabolic syndrome, accumulation of its components and risk of knee and hip replacement for osteoarthritis in community-dwelling older adults.Osteoarthritis and cartilage open · 2026Article
- Self-reported physical activity and risk of primary knee replacement for osteoarthritis: a competing risks cohort analysis.BMC musculoskeletal disorders · 2025Article
- Biopsychosocial Determinants for Total Knee Replacement Decisions Among Older Adults With Chronic Knee Osteoarthritis: A Scoping Review.Geriatric orthopaedic surgery & rehabilitation · 2025Review
- Association between Low Serum Creatinine Levels and Knee Osteoarthritis in Koreans without Renal Insufficiency.Yonsei medical journal · 2024Article
- Decreased Risk of Knee Osteoarthritis with Taller Height in an East Asian Population: A Nationwide Cohort Study.Journal of clinical medicine · 2023Article
- Article
- The Regional Burden and Disability-Adjusted Life Years of Knee Osteoarthritis in Kazakhstan 2014-2020.Biomedicines · 2023Article
- Understanding the risk of developing weight-related complications associated with different body mass index categories: a systematic review.Diabetology & metabolic syndrome · 2022Review
- Obesity is associated with an increased risk of undergoing knee replacement in Australia.ANZ journal of surgery · 2022Article
- Prediction models for the risk of total knee replacement: development and validation using data from multicentre cohort studies.The Lancet. Rheumatology · 2022Article
- Estimating the Prevalence of Knee Pain and the Association between Illness Perception Profiles and Self-Management Strategies in the Frederiksberg Cohort of Elderly Individuals with Knee Pain: A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- Developing prediction models for total knee replacement surgery in patients with osteoarthritis: Statistical analysis plan.Osteoarthritis and cartilage open · 2020Article
- Occupation and risk of knee osteoarthritis and knee replacement: A longitudinal, multiple-cohort study.Seminars in arthritis and rheumatism · 2020Article
- Prevalence of total hip and knee arthroplasty in former National Football League players: comparison with the general US population and other populations of professional athletes.BMJ open sport & exercise medicine · 2020Article
- Article
- The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology.Metabolites · 2018Review
- Higher mid-term revision rates of posterior stabilized compared with cruciate retaining total knee arthroplasties: 133,841 cemented arthroplasties for osteoarthritis in the Netherlands in 2007-2016.Acta orthopaedica · 2018Observational
- Knowledge and attitude towards total knee arthroplasty among the public in Saudi Arabia: a nationwide population-based study.International orthopaedics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) of the knee is a common and disabling condition. We wanted to investigate the modifiable risk factors Body Mass Index (BMI) and physical activity, using knee replacement (KR) as a marker for severely symptomatic disease, focusing on the interaction between these risk factors.
methods315,495 participants (mean age 43.0 years) from national health screenings were followed prospectively with respect to KR identified by linkage to the Norwegian Arthroplasty Register. Data were analysed by Cox proportional hazard regression.
resultsDuring 12 years of follow up 1,323 individuals received KR for primary OA. There was a dose-response relationship between BMI and heavy labour, and later KR. Comparing the highest versus the lowest quarter of BMI, the relative risk was 6.2 (95% CI: 4.2-9.0) in men and 11.1 (95% CI: 7.8-15.6) in women. Men reporting intensive physical activity at work had a relative risk of 2.4 (95% CI: 1.8-3.2) versus men reporting sedentary activity at work, the corresponding figure in women being 2.3 (95% CI: 1.7-3.2). The effect of BMI and physical activity at work was additive. The heaviest men with the most strenuous work had a RR of 11.7 (95% CI: 5.9-23.1) compared to the ones with the lowest BMI and most sedentary work. For women the corresponding RR was 15.8 (95% CI: 8.2-30.3). There was no association between physical activity during leisure and KR.
conclusionWe found that a high BMI and intensive physical activity at work both contribute strongly to the risk of having a KR. As the two risk factors seem to act independently, people with strenuous physical work with a high BMI are at particularly high risk for severely disabling OA of the knee, and should be targeted with effective preventive measures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.