ArticleIEEE transactions on bio-medical engineering2014
High-definition transcranial direct current stimulation induces both acute and persistent changes in broadband cortical synchronization: a simultaneous tDCS-EEG study.
Article in IEEE transactions on bio-medical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Combined Use of Electroencephalography and Transcranial Electrical Stimulation: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Impact of Electrical Stimulation on Mental Stress, Depression, and Anxiety: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects.Frontiers in neuroscience · 2022Pooled it
- Investigating the feasibility and safety of transcranial infraslow gray noise stimulation as a potential treatment for generalized anxiety disorder.Scientific reports · 2025Trial
- Anodal HD-tDCS on the dominant anterior temporal lobe and dorsolateral prefrontal cortex: clinical results in patients with mild cognitive impairment.Alzheimer's research & therapy · 2024Trial
- Effects of active and sham tDCS on the soleus H-reflex during standing.Experimental brain research · 2023Trial
- When brain stimulation backfires: the effects of prefrontal cortex stimulation on impulsivity.Social cognitive and affective neuroscience · 2022Trial
- Varied Response of EEG Rhythm to Different tDCS Protocols and Lesion Hemispheres in Stroke Subjects with Upper Limb Dysfunction.Neural plasticity · 2022Trial
- Development of a transcranial direct current stimulation device based on current limiter for simultaneous measurement of electroencephalography: A feasibility study.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Trial
- Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing.NeuroImage. Clinical · 2019Trial
- High-definition transcranial direct current stimulation (HD-tDCS) of left dorsolateral prefrontal cortex affects performance in Balloon Analogue Risk Task (BART).Brain and behavior · 2018Trial
- Effect of Anodal-tDCS on Event-Related Potentials: A Controlled Study.BioMed research international · 2016Trial
- Absence of evidence for post-training tDCS effects on motor memory consolidation and premotor-primary motor cortex interaction: a resting-state EEG study.Frontiers in human neuroscience · 2026Article
- Harnessing electroencephalography connectomes for cognitive and clinical neuroscience.Nature biomedical engineering · 2025Review
- The "Cocombola Study": A Physical Phantom Model for tDCS-Induced Electric Field Distribution.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Effects of dendritic CaJournal of computational neuroscience · 2025Article
- A review on the reporting and assessment of adverse effects associated with high-definition transcranial direct current stimulation.Frontiers in human neuroscience · 2025Review
- Advanced Methodology for Neurophysiological Analysis and Biomarker Development: Time-Frequency and Source-Localization Approaches.Advances in neurobiology · 2024Review
- Effect of tDCS on corticomuscular coupling and the brain functional network of stroke patients.Medical & biological engineering & computing · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The goal of this study was to develop methods for simultaneously acquiring electrophysiological data during high-definition transcranial direct current stimulation (tDCS) using high-resolution electroencephalography (EEG). Previous studies have pointed to the after-effects of tDCS on both motor and cognitive performance, and there appears to be potential for using tDCS in a variety of clinical applications. However, little is known about the real-time effects of tDCS on rhythmic cortical activity in humans due to the technical challenges of simultaneously obtaining electrophysiological data during ongoing stimulation. Furthermore, the mechanisms of action of tDCS in humans are not well understood. We have conducted a simultaneous tDCS-EEG study in a group of healthy human subjects. Significant acute and persistent changes in spontaneous neural activity and event-related synchronization (ERS) were observed during and after the application of high-definition tDCS over the left sensorimotor cortex. Both anodal and cathodal stimulation resulted in acute global changes in broadband cortical activity which were significantly different than the changes observed in response to sham stimulation. For the group of eight subjects studied, broadband individual changes in spontaneous activity during stimulation were apparent both locally and globally. In addition, we found that high-definition tDCS of the left sensorimotor cortex can induce significant ipsilateral and contralateral changes in event-related desynchronization and ERS during motor imagination following the end of the stimulation period. Overall, our results demonstrate the feasibility of acquiring high-resolution EEG during high-definition tDCS and provide evidence that tDCS in humans directly modulates rhythmic cortical synchronization during and after its administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.