Evidence map›Paper›PMID 24956510›Full record

ReviewMicrovascular research2014

Imaging the lymphatic system.

Lance L Munn, Timothy P Padera

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Microvascular research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517852 nacompletednot on this mapstarted 2018, after this paper: background citation

Intravital Microscopy (IVM) in Patients With Peritoneal Carcinomatosis (PC)

TypeinterventionalSponsorMayo ClinicRan2018 to 2023Enrolled30ConditionsPeritoneal CarcinomatosisArmsHuman Intravital Microscopy
NCT03823144 narecruitingnot on this mapstarted 2019, after this paper: background citation

Intravital Microscopy (IVM) in Human Solid Tumors

TypeinterventionalSponsorMayo ClinicRan2019 to 2027Enrolled85ConditionsSolid Tumor, Adult, Clinical Stage IV Gastric Cancer AJCC v8, Malignant Solid Neoplasm, Metastatic Colorectal CarcinomaArmsDiagnostic Microscopy, Fluorescein Sodium Injection
3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Microsurgery guided by sequential preoperative lymphography usingEuropean journal of nuclear medicine and molecular imaging · 2017
    Trial
  2. Quantification of Lacteal Contractility by Live Intravital Imaging.Microcirculation (New York, N.Y. : 1994) · 2026
    Article
  3. Article
  4. Review
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  10. Review
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  14. Article
  15. Article
  16. Article
  17. Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lance L MunnDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: lmunn@mgh.harvard.edu.
Timothy P PaderaDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: tpadera@mgh.harvard.edu.

Funding

Vascular Normalization: Rolse of Perivascular CellsP01CA080124 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2000 to 2016
$35.0M
TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Systems biology of lymphatic transportR01HL128168 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L., PADERA, TIMOTHY P · 2015 to 2019
$2.9M
Characterizing lymphatic micrometastases: prognostic and therapeutic implicationsDP2OD008780 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2011 to 2011
$2.6M
Development of a preclinical optical frequency domain angiography instrumentR01CA163528 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VAKOC, BENJAMIN JAMES · 2012 to 2016
$1.9M
Flow-based remodeling and function of tumor vasculatureR01CA149285 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2010 to 2013
$1.3M
Lymphatic RadiobiologyR00CA137167 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2011 to 2013
$699k
Characterization of lymphatic contraction during infectionR21AI097745 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2012 to 2013
$480k
NCI NIH HHS P01 CA080124NCI NIH HHS R00 CA137167NCI NIH HHS R00-CA137167NCI NIH HHS R01 CA149285NCI NIH HHS R01CA149285NCI NIH HHS R01 CA163528NHLBI NIH HHS R01 HL128168NIAID NIH HHS R21 AI097745NIAID NIH HHS R21-AI097745NIBIB NIH HHS P41 EB015903NIH HHS DP2 OD008780NIH HHS DP2-OD008780
6 · The paper itself

Abstract

Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedures. Imaging lymphatic anatomy and function also plays an important role in experimental studies of lymphatic development and function, where spatial resolution and accessibility are better. Here, we review technologies for visualizing and imaging the lymphatic system for clinical applications. We then describe the use of lymphatic imaging in experimental systems as well as some of the emerging technologies for improving these methodologies.

Indexed as

AnimalsContrast MediaDiagnostic ImagingHomeostasisHumansLymphatic MetastasisLymphatic SystemLymphatic VesselsLymphedemaLymphographyMiceNeoplasm MetastasisNeoplasmsPositron-Emission TomographyRadionuclide ImagingSpectroscopy, Near-InfraredContrast MediaClinicalFluorescenceImagingLymphatic functionLymphatic metastasisLymphatic vesselsLymph nodeLymphographyModelsTechnologies

Identifiers

PMID24956510
PMCPMC4268344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.