ArticlePloS one2014
Betaine and beet molasses enhance L-lactic acid production by Bacillus coagulans.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
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- RNA-Seq Insight into the Impact and Mechanisms of Methyl Donor and Glycine Betaine Osmoprotectant on Polyketide Secondary Metabolism inJournal of fungi (Basel, Switzerland) · 2025Article
- Influence of Infill Level and Post-Processing on Physical Parameters and Betaine Content of Enriched 3D-Printed Sweet Snacks.Foods (Basel, Switzerland) · 2023Article
- Regulation of CytochromeCells · 2021Review
- Kinetic characteristics of long-term repeated fed-batch (LtRFb) l-lactic acid fermentation by aEngineering in life sciences · 2020Article
- Inositol as a new enhancer for improving lipid production and accumulation in Schizochytrium sp. SR21.Environmental science and pollution research international · 2019Article
- Genomic Characterization and Probiotic Potency ofFrontiers in microbiology · 2018Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactic acid is an important chemical with various industrial applications, and it can be efficiently produced by fermentation, in which Bacillus coagulans strains present excellent performance. Betaine can promote lactic acid fermentation as an effective osmoprotectant. Here, positive effect of betaine on fermentation by B. coagulans is revealed. Betaine could enhance lactic acid production by protecting l-LDH activity and cell growth from osmotic inhibition, especially under high glucose concentrations and with poor organic nitrogen nutrients. The fermentation with 0.05 g/L betaine could produce 17.9% more lactic acid compared to the fermentation without betaine. Beet molasses, which is rich in sucrose and betaine, was utilized in a co-feeding fermentation and raised the productivity by 22%. The efficient lactic acid fermentation by B. coagulans is thus developed by using betaine and beet molasses.
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