ArticleAmerican journal of respiratory and critical care medicine2014
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Telomere-associated non-malignant pulmonary diseases: Pathogenic mechanisms and therapeutic strategies.Acta pharmaceutica Sinica. B · 2026Review
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Menopause is not associated with asthma or severe asthma.The journal of allergy and clinical immunology. In practice · 2025Article
- Senotherapy for chronic lung disease.Pharmacological reviews · 2025Review
- Leukocyte telomere length and attrition in association with disease severity in cystic fibrosis patients.Aging · 2024Article
- Undersized telomeres in regulatory T cells link to the pathogenesis of allergic rhinitis.iScience · 2024Article
- Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study.Frontiers in genetics · 2023Article
- Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Article
- Short and dysfunctional telomeres protect from allergen-induced airway inflammation.Aging cell · 2021Article
- Airway hyperresponsiveness development and the toxicity of PM2.5.Environmental science and pollution research international · 2021Review
- Article
- Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum.Frontiers in immunology · 2021Review
- Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma.Oxidative medicine and cellular longevity · 2021Review
- Interleukin (IL)-15 significance in aging associated asthma pathogenesis.International journal of cell biology and physiology · 2020Article
- Potential Role of Cellular Senescence in Asthma.Frontiers in cell and developmental biology · 2020Review
- Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study.Environmental health : a global access science source · 2019Article
- Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.Frontiers in immunology · 2019Review
- Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers.Frontiers in immunology · 2017Article
- Telomere length and periodontal attachment loss: a prospective cohort study.Journal of clinical periodontology · 2016Article
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
rationaleAsthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging.
objectivesTo test whether chronic asthma is associated with a proposed biomarker of accelerated aging, leukocyte telomere length.
methodsAsthma was ascertained prospectively in the Dunedin Multidisciplinary Health and Development Study cohort (n = 1,037) at nine in-person assessments spanning ages 9-38 years. Leukocyte telomere length was measured at ages 26 and 38 years. Asthma was classified as life-course-persistent, childhood-onset not meeting criteria for persistence, and adolescent/adult-onset. We tested associations between asthma and leukocyte telomere length using regression models. We tested for confounding of asthma-leukocyte telomere length associations using covariate adjustment. We tested serum C-reactive protein and white blood cell counts as potential mediators of asthma-leukocyte telomere length associations. MEASUREMENTS AND MAIN
resultsStudy members with life-course-persistent asthma had shorter leukocyte telomere length as compared with sex- and age-matched peers with no reported asthma. In contrast, leukocyte telomere length in study members with childhood-onset and adolescent/adult-onset asthma was not different from leukocyte telomere length in peers with no reported asthma. Adjustment for life histories of obesity and smoking did not change results. Study members with life-course-persistent asthma had elevated blood eosinophil counts. Blood eosinophil count mediated 29% of the life-course-persistent asthma-leukocyte telomere length association.
conclusionsLife-course-persistent asthma is related to a proposed biomarker of accelerated aging, possibly via systemic eosinophilic inflammation. Life histories of asthma can inform studies of aging.
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