ArticleBehavioral neuroscience2014
Mammilliothalamic tract lesions disrupt tests of visuo-spatial memory.
Article in Behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Simulating object recognition with the Standard Operating Procedures (SOP) model.Psychonomic bulletin & review · 2026Review
- A dorsal subiculum-medial mammillary body pathway for spatial memory.Molecular psychiatry · 2025Article
- Impairments of spatial memory retrieval via medial mammillary body dysfunction in Alzheimer's disease model.Translational psychiatry · 2025Article
- Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies.Scientific reports · 2024Article
- Neurochemistry of the mammillary body.Brain structure & function · 2023Review
- Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease.Science translational medicine · 2023Article
- Understanding the aging hypothalamus, one cell at a time.Trends in neurosciences · 2022Review
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- The anterior thalamic nuclei and nucleus reuniens: So similar but so different.Neuroscience and biobehavioral reviews · 2020Review
- Mammillothalamic Disconnection Alters Hippocampocortical Oscillatory Activity and Microstructure: Implications for Diencephalic Amnesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- The importance of mammillary body efferents for recency memory: towards a better understanding of diencephalic amnesia.Brain structure & function · 2017Article
- Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms.Biological psychiatry · 2017Review
- Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions.Neuroscience · 2016Article
- Mammillary Bodies in Alzheimer's Disease: A Golgi and Electron Microscope Study.American journal of Alzheimer's disease and other dementias · 2016Article
- Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte.Scientific reports · 2016Article
- How do mammillary body inputs contribute to anterior thalamic function?Neuroscience and biobehavioral reviews · 2015Review
- Advances in the behavioural testing and network imaging of rodent recognition memory.Behavioural brain research · 2015Review
- The mammillary bodies and memory: more than a hippocampal relay.Progress in brain research · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mammillary bodies and their projections via the mammilliothalamic tract to the anterior thalamic nuclei are known to be important for spatial memory in rodents, but their precise role remains unclear. To determine whether transection of the mammilliothalamic tract can produce deficits on tests of spatial memory even when the navigational demands placed on the animal are limited, rats with discrete mammilliothalamic tract lesions were tested on the ability to use distal visual cues to discriminate between 2 locations within a room, irrespective of the direction traveled (Experiment 1). Animals with mammilliothalamic tract lesions acquired this task more slowly and less accurately than control animals. Consistent with this impairment in discriminating different spatial locations, the same lesions also severely disrupted object-in-place memory but spared performance on standard tests of object recognition memory (Experiment 2). Finally, to compare performance on a task that is known to be sensitive to mammilliothalamic transection and requires animals to actively navigate within their environment, the effect of the lesions on spatial working memory in the radial-arm maze was examined. Taken together, the results suggest that even when there are little or no navigational demands, mammilliothalamic tract damage still results in impoverished encoding of spatial location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.