ArticlePsychology and aging2014
Genetic complexity of episodic memory: a twin approach to studies of aging.
Article in Psychology and aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Early Cortical Microstructural Changes in Aging Are Linked to Vulnerability to Alzheimer's Disease Pathology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men.Alzheimer's research & therapy · 2024Article
- Sex-specific genetic architecture of late-life memory performance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.Neurotrauma reports · 2024Article
- Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age.Journal of the International Neuropsychological Society : JINS · 2023Article
- Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood.The Gerontologist · 2023Article
- Alzheimer's Disease Polygenic Scores Predict Changes in Episodic Memory and Executive Function Across 12 Years in Late Middle Age.Journal of the International Neuropsychological Society : JINS · 2023Article
- Paradoxical cognitive trajectories in men from earlier to later adulthood.Neurobiology of aging · 2022Article
- MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.Neuropsychology · 2021Article
- How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10-12 Year Change.Journal of Alzheimer's disease : JAD · 2021Article
- Association of baseline semantic fluency and progression to mild cognitive impairment in middle-aged men.Neurology · 2020Article
- Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease.Brain imaging and behavior · 2020Article
- Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment.Autism research : official journal of the International Society for Autism Research · 2020Article
- Association of neuroinflammation with episodic memory: a [Brain communications · 2020Article
- Metabolic Profiling of Cognitive Aging in Midlife.Frontiers in aging neuroscience · 2020Article
- Extensive memory testing improves prediction of progression to MCI in late middle age.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Genetic and environmental architecture of processing speed across midlife.Neuropsychology · 2019Article
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13 authors.
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Abstract
Episodic memory change is a central issue in cognitive aging, and understanding that process will require elucidation of its genetic underpinnings. A key limiting factor in genetically informed research on memory has been lack of attention to genetic and phenotypic complexity, as if "memory is memory" and all well-validated assessments are essentially equivalent. Here we applied multivariate twin models to data from late-middle-aged participants in the Vietnam Era Twin Study of Aging to examine the genetic architecture of 6 measures from 3 standard neuropsychological tests: the California Verbal Learning Test-2, and Wechsler Memory Scale-III Logical Memory (LM) and Visual Reproductions (VR). An advantage of the twin method is that it can estimate the extent to which latent genetic influences are shared or independent across different measures before knowing which specific genes are involved. The best-fitting model was a higher order common pathways model with a heritable higher order general episodic memory factor and three test-specific subfactors. More importantly, substantial genetic variance was accounted for by genetic influences that were specific to the latent LM and VR subfactors (28% and 30%, respectively) and independent of the general factor. Such unique genetic influences could partially account for replication failures. Moreover, if different genes influence different memory phenotypes, they could well have different age-related trajectories. This approach represents an important step toward providing critical information for all types of genetically informative studies of aging and memory.
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