ArticleJournal of functional biomaterials2012
Biocompatibility of chitosan carriers with application in drug delivery.
Article in Journal of functional biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration.TheScientificWorldJournal · 2017Pooled it
- A Comprehensive Review on Engineering Release at the Molecular Level: Role of Functional Groups in Polysaccharide-Based Drug Delivery.Materials (Basel, Switzerland) · 2026Review
- Gelatin-Incorporated Chitosan-TPP Nanocomposites Enhanced Cumulative and Sustained Bovine Serum Albumin Release.ACS omega · 2026Article
- Long-term moxifloxacin release from a chitosan-based antibacterial coating on polyethylene for biomedical applications.RSC advances · 2026Article
- Chitosan Sponges as Next-Generation Biomaterials for Dental Tissue Engineering and Periodontal Regeneration.Pharmaceutics · 2025Review
- Enhanced Piezoelectricity in Sustainable-By-Design Chitosan Nanocomposite Soft Thin Films for Green Sensors.ACS nano · 2025Article
- Zinc-integrated PLGA/chitosan nanofiber mesh: a platform for wound healing applications.RSC advances · 2025Article
- Article
- Melatonin/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach.International journal of molecular sciences · 2025Review
- Förster Resonance Energy Transfer (FRET) Demonstrates In Vitro Chitosan-Coated Nanocapsules Suitability for Intranasal Brain Delivery.ACS applied materials & interfaces · 2025Article
- pH-Responsive Amphiphilic Chitosan-Lignin System Loaded with Samarium Oxide Nanoparticles for Curcumin Delivery.ACS omega · 2025Article
- Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration.Acta biomaterialia · 2025Article
- Development of Curcumin-Loaded TiOPolymers · 2025Article
- The Effect ofInternational journal of molecular sciences · 2025Article
- Nano-Based Drug Delivery Systems for Managing Diabetes: Recent Advances and Future Prospects.International journal of nanomedicine · 2025Review
- Advanced therapeutic strategy for managing surgical site infections with natural nanoemulsion-antimicrobial combination.Frontiers in pharmacology · 2025Article
- Keratin Additive for Cellular Adhesion in Transcutaneous Prosthetics.Journal of tissue engineering and regenerative medicine · 2025Article
- Review
- A Review of Chitosan-Based Materials for Biomedical, Food, and Water Treatment Applications.Materials (Basel, Switzerland) · 2024Review
- From Burst to Sustained Release: The Effect of Antibiotic Structure Incorporated into Chitosan-Based Films.Antibiotics (Basel, Switzerland) · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity to produce drug delivery systems, ensuring the biocompatibility of the drug delivery vehicles is a highly relevant issue. Nevertheless, this subject is not addressed as frequently as desired and even though the application of chitosan carriers has been widely explored, the demonstration of systems biocompatibility is still in its infancy. In this review, addressing the biocompatibility of chitosan carriers with application in drug delivery is discussed and the methods used in vitro and in vivo, exploring the effect of different variables, are described. We further provide a discussion on the pros and cons of used methodologies, as well as on the difficulties arising from the absence of standardization of procedures.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.