Evidence map›Paper›PMID 24955241›Full record

ArticleEnvironmental science. Nano2014

Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential.

Georgios A Sotiriou, Christa Watson, Kimberly M Murdaugh, Thomas H Darrah, Georgios Pyrgiotakis, Alison Elder, Joseph D Brain, Philip Demokritou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science. Nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Georgios A SotiriouDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.
Christa WatsonDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.
Kimberly M MurdaughDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA ; School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.
Thomas H DarrahSchool of Earth Sciences, 231 Mendenhall Laboratory, The Ohio State University, Columbus, OH 43210, USA.
Georgios PyrgiotakisDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.
Alison ElderUniversity of Rochester, Department of Environmental Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Joseph D BrainDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.
Philip DemokritouDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
NHLBI NIH HHS T32 HL007118NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Zinc oxide (ZnO) nanoparticles absorb UV light efficiently while remaining transparent in the visible light spectrum rendering them attractive in cosmetics and polymer films. Their broad use, however, raises concerns regarding potential environmental health risks and it has been shown that ZnO nanoparticles can induce significant DNA damage and cytotoxicity. Even though research on ZnO nanoparticle synthesis has made great progress, efforts on developing safer ZnO nanoparticles that maintain their inherent optoelectronic properties while exhibiting minimal toxicity are limited. Here, a safer-by-design concept was pursued by hermetically encapsulating ZnO nanorods in a biologically inert, nanothin amorphous SiO

Identifiers

PMID24955241
PMCPMC4060637

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.