ReviewOxidative medicine and cellular longevity2014
Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.
Review in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Effects of a High-Glucose Diet onACS omega · 2026Article
- CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III.Communications biology · 2026Article
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- Enhancing Boron Neutron Capture Therapy (BNCT) with Materials Based on COSAN-Functionalized Nanoparticles.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Visualization of scientific production in Caenorhabditis elegans: a bibliometric analysis (1980-2023).Genomics & informatics · 2024Article
- PemB, a type III secretion effector inHeliyon · 2024Article
- A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research.Scientific reports · 2024Article
- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
- Ameliorative effects of Bifidobacterium longum peptide-1 on benzo(α)pyrene induced oxidative damages via daf-16 in Caenorhabditis elegans.Cell stress & chaperones · 2023Article
- Chemical Components and Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2023Article
- Insights into the Oxidative Stress Alleviation Potential of Enzymatically PreparedMolecules (Basel, Switzerland) · 2023Article
- Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-DeficientMolecules (Basel, Switzerland) · 2023Article
- Antiobesity and Antioxidative Effect of Fermented Brown Rice Using In Vitro with In VivoLife (Basel, Switzerland) · 2023Article
- Maternal Gliadin Intake Reduces Oocyte Quality with Chromosomal Aberrations and Increases Embryonic Lethality through Oxidative Stress in aNutrients · 2022Article
- A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish.Genes · 2022Article
- Oxidative Stress Protection by Canary Seed (Nutrients · 2022Article
- Article
- Oxidation and Antioxidation of Natural Products in the Model OrganismAntioxidants (Basel, Switzerland) · 2022Review
- The endophytic fungusFrontiers in pharmacology · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo. This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes. C. elegans displays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance of C. elegans as an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.