ArticleInternational journal of clinical and experimental medicine2014
CA 125 and other tumor markers in uterine leiomyomas and their association with lesion characteristics.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Identification of diagnostic blood indicators associated with adenomyosis: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- CA125 as a Potential Biomarker in Non-Malignant Serous Effusions: Diagnostic and Prognostic Considerations.Journal of clinical medicine · 2025Review
- AMH and Kisspeptin Receptor Expression in Rare Hydropic Leiomyoma: A Case Study.The American journal of case reports · 2025Article
- Evaluating CA-125 and PET/CT for cancer detection in idiopathic inflammatory myopathies.Rheumatology (Oxford, England) · 2025Article
- Complete Cystic Degeneration of a Uterine Myoma Posing a Diagnostic Dilemma.Case reports in radiology · 2025Article
- The Impact of Adenomyosis on Pregnancy.Biomedicines · 2024Review
- Validation of an In Vitro Diagnostic Test for Endometriosis: Impact of Confounding Medical Conditions and Lesion Location.International journal of molecular sciences · 2024Article
- Hydropic leiomyoma-like ovarian tumor: a case report.Fukushima journal of medical science · 2024Article
- Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels.Frontiers in oncology · 2024Article
- Development and Validation of a Nomogram to Predict the Risk of Special Uterine Leiomyoma Pathological Types or Leiomyosarcoma in Postmenopausal Women: A Retrospective Study.Risk management and healthcare policy · 2024Article
- Stroke in Patients With Common Noncancerous Gynecologic Diseases: A Multicenter Study in Japan.Neurology. Clinical practice · 2023Article
- Diagnostic Challenge: Distinguishing Uterine Fibroid with Cystic Degeneration vs. Ovarian Cystic Malignancy. A Case Report.Journal of radiology case reports · 2023Article
- Notes on the morphological features of cotyledonary dissecting leiomyoma, which is rare in clinical practice.Translational cancer research · 2023Article
- Importance of diagnostic methods for round ligament leiomyomas in clinical practice.Quantitative imaging in medicine and surgery · 2023Article
- Retroperitoneal Hydropic Leiomyoma Mimicking an Ovarian Cyst.Case reports in obstetrics and gynecology · 2022Article
- An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women.Przeglad menopauzalny = Menopause review · 2021Article
- Abdominopelvic leiomyoma with large ascites: A case report and review of the literature.World journal of clinical cases · 2021Article
- Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma.Diagnostics (Basel, Switzerland) · 2020Article
- Vaginal leiomyoma: medical imaging and diagnosis in a resource low tertiary hospital: case report.BMC women's health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the factors associated with serum levels of several tumor markers in a group of patients operated for uterine myoma. One hundred thirty-seven female patients operated for uterine myoma were included. Serum samples were examined for CA 125, CA 19-9, CA 15-3, carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) levels as part of routine workup. Pathological and morphological characteristics of the patients were retrieved from medical records. The mean age was 46.7 ± 8.8 years (range, 22-85 y). Abnormally high levels of CA 125, CA 19-9, CA 15-3, CEA, and AFP were found in 19.7%, 6.6%, 5.1%, 3.7%, and 1.5% of the patients, respectively. Patients with additional adenomyosis and patients with at least one large myoma (≥ 5 cm diameter) had significantly higher levels of CA 125. Multivariate analysis identified coexistence of adenomyosis (OR 7.7 [95% CI, 2.6-23.0], p < 0.001) and presence of at least one large myoma (OR 5.6 [1.4-22.8], p = 0.016) as independent predictors of abnormally high CA 125 levels. CA 125 levels are affected by the tumor size and coexistence of adenomyosis in uterine leiomyomas. Indirect mechanisms caused by large myoma size such as peritoneal irritation may be responsible for CA 125 elevations.
Indexed as
Identifiers
24955185PMC4057864W56689114What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.