Evidence map›Paper›PMID 24955158›Full record

ArticleInternational journal of clinical and experimental medicine2014

Immunoregulation effect of crude extract of C. elegans on allergic asthma.

Yuee Huang, Yongjun Zhang, Chaopin Li, Yuxin Jiang, Lianping He, Wei Guo, Min Guo, Wei Gong

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Therapeutic Effects of a Long-Acting Cholinergic Receptor Blocker, Tiotropium Bromide, on Asthma.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Trial
  2. Review
  3. Use of Natural Products in Asthma Treatment.Evidence-based complementary and alternative medicine : eCAM · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuee HuangLaboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; School of Public Health, Wannan Medical University Wuhu 241001, China.
Yongjun ZhangDepartment of Electrocardiograph, Yijishan Hospital of Wannan Medical University Wuhu 241001, China.
Chaopin LiLaboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; School of Basic Medicine, Wannan Medical University Wuhu 241002, China.
Yuxin JiangSchool of Basic Medicine, Wannan Medical University Wuhu 241002, China.
Lianping HeSchool of Public Health, Wannan Medical University Wuhu 241001, China.
Wei GuoSchool of Basic Medicine, Wannan Medical University Wuhu 241002, China.
Min GuoSchool of Basic Medicine, Wannan Medical University Wuhu 241002, China.
Wei GongSchool of Basic Medicine, Wannan Medical University Wuhu 241002, China.
Wannan Medical College · CNAnhui University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledTo explore effects of natural crude extract of C. elegans on treatment of asthma.

methodObtain crude extract of C. elegans from synchronically incubated C. elegans via centrifugation, washing and ultrasonic emulsification, etc.; measure C. elegans's protein molecular weight via SDS-polyacrylamide gel electrophoresis (SDS-PAG electrophoresis); construct animal models of asthma with 6-8-week-old BALB/c female mice sensitized by chicken ovalbumin (OVA); conduct immunotherapy on animals with asthma with different doses of mixture of C. elegans and OVA (COM) respectively; take PBS buffer group and OVA group as control groups; conduct inspection of cell factors and differential count of cells in serum IgE, IgG1 and IgG2a antibodies and bronchoalveolar lavage fluid (BALF) via enzyme linked immunosorbent assay (ELISA); and incise lung tissue for pathology observation.

resultC. elegans's protein molecular weight is about 50 kd. In bronchoalveolar lavage fluid (BALF) of OVA group, cell factors IL-5 and IL-13 are more than those in PBS buffer group, but IL-2 and IFN-γ are less than those in PBS buffer group; these differences are of statistical significance (P<0.05). Total cellular score and number of eosinophile granulocyte in BALF of OVA group are more than those in PBS buffer group (P<0.05), and the difference in serum IgE, IgG1 and IgG2a between these two groups is of statistical significance (P<0.05). For groups treatment by different doses of COM, cell factors IL-5 and IL-13 in bronchoalveolar lavage fluid (BALF) are less than those in OVA group, but IL-2 and IFN-γ are more than those in OVA group; these differences are of statistical significance (P<0.05). Total cellular score and number of eosinophile granulocyte in BALF of COM treatment groups are less than those in OVA group (P<0.05); serum IgE and IgG1 less than those in OVA group, but IgG2a is more than that in OVA group; these differences are of statistical significance (P<0.05).

conclusionThe natural crude extract of C. elegans has immunoregulation to animals with asthma.

Indexed as

asthmaCaenorhabditis eleganscrude extractimmunoregulation

Identifiers

PMID24955158
PMCPMC4057837
OpenAlexW1431831055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.