ArticleTheranostics2014
Prototype nerve-specific near-infrared fluorophores.
Article in Theranostics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 99 citations in OpenAlex.
- Advances in Optical and Fluorescence Imaging for Surgical Management of Thyroid Cancer.Cancers · 2026Review
- BBB-Permeable Near-Infrared Oxazine Fluorophores for White Matter Tract Imaging.bioRxiv : the preprint server for biology · 2026Article
- Tumor-Embedded Nerve Surgery Using Dual-Channel Intraoperative Imaging Probes.ACS applied materials & interfaces · 2025Article
- Matrix-designed bright near-infrared fluorophores for precision peripheral nerve imaging.Biomaterials · 2025Article
- Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial.Nature communications · 2025Article
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Nerve-Sparing Gynecologic Surgery Enabled by A Near-Infrared Nerve-Specific Fluorophore Using Existing Clinical Fluorescence Imaging Systems.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Shining a Light on Venom-Peptide Receptors: Venom Peptides as Targeted Agents for In Vivo Molecular Imaging.Toxins · 2024Review
- A robotic system for automated chemical synthesis of therapeutic agents.Materials advances · 2024Article
- Realizing real-time optical molecular imaging in peripheral nerve tissue via Rhodamine B.Frontiers in medicine · 2024Article
- Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.Current opinion in chemical biology · 2023Review
- The TOFr of 0.75 to 0.85 is the optimal timing for IONM during thyroid surgery: a prospective observational cohort study.BMC anesthesiology · 2023Observational
- A Truncated 14-Amino-Acid Myelin Protein-Zero-Targeting Peptide for Fluorescence-Guided Nerve-Preserving Surgery.Biomolecules · 2023Article
- Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability.Advanced healthcare materials · 2023Article
- Ovarian cancer-targeted near-infrared fluorophores for fluorescence-guided surgery.Annals of translational medicine · 2023Article
- Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery.Molecular imaging and biology · 2023Review
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- Nerve Targeting via Myelin Protein Zero and the Impact of Dimerization on Binding Affinity.Molecules (Basel, Switzerland) · 2022Article
- Microwave-Assisted Synthesis of the Red-Shifted Pentamethine Tetrahydroxanthylium Core with Absorbance within the Near Infrared-II Window.ACS pharmacology & translational science · 2022Article
- P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging.Biomaterials research · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Nerve preservation is an important issue during most surgery because accidental transection or injury results in significant morbidity, including numbness, pain, weakness, or paralysis. Currently, nerves are still identified only by gross appearance and anatomical location during surgery, without intraoperative image guidance. Near-infrared (NIR) fluorescent light, in the wavelength range of 650-900 nm, has the potential to provide high-resolution, high-sensitivity, and real-time avoidance of nerve damage, but only if nerve-specific NIR fluorophores can be developed. In this study, we evaluated a series of Oxazine derivatives to highlight various peripheral nerve structures in small and large animals. Among the targeted fluorophores, Oxazine 4 has peak emission near into the NIR, which provided nerve-targeted signal in the brachial plexus and sciatic nerve for up to 12 h after a single intravenous injection. In addition, recurrent laryngeal nerves were successfully identified and highlighted in real time in swine, which could be preserved during the course of thyroid resection. Although optical properties of these agents are not yet optimal, chemical structure analysis provides a basis for improving these prototype nerve-specific NIR fluorophores even further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.