ArticleJournal of ovarian research2014
Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age.
Article in Journal of ovarian research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of ovarian stimulation and embryonic aneuploidy in in vitro fertilization cycles with preimplantation genetic testing: A narrative systematic review.JBRA assisted reproduction · 2022Pooled it
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- Defining associated factors for total fertilization failure and embryo development arrest in intracytoplasmic sperm injection cycles.BMC women's health · 2026Article
- Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.International journal of molecular sciences · 2026Review
- Impact of rapidly cleaving embryos on blastocyst formation and single-blastocyst transfer outcomes.Frontiers in endocrinology · 2026Article
- Ribosome dysregulation and intervention in age-related infertility.Cell reports. Medicine · 2025Article
- The chromosomal challenge of human embryos: Mechanisms and fundamentals.HGG advances · 2025Review
- Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles.BMC pregnancy and childbirth · 2025Article
- The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos.Journal of ovarian research · 2024Article
- Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest.Nature cell biology · 2024Article
- Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos.Genome medicine · 2023Article
- The Clinical Significance of Embryonic Chromosomal Errors in Recurrent Pregnancy Loss: an Analysis of 1107 Miscarriages.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state.PLoS biology · 2022Article
- Cleavage-stage human embryo arrest, is it embryo genetic composition or others?Reproductive biology and endocrinology : RB&E · 2022Article
- Disposition of embryos from women who only produced morphologically poor embryos on day three.Biomedical journal · 2022Observational
- Short-term Western-style diet negatively impacts reproductive outcomes in primates.JCI insight · 2021Article
- Non-inferiority of cleavage-stage versus blastocyst-stage embryo transfer in poor prognosis IVF patients (PRECiSE trial): study protocol for a randomized controlled trial.Reproductive health · 2020Article
- Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview.Reproductive biology and endocrinology : RB&E · 2019Article
- Contraction behaviour reduces embryo competence in high-quality euploid blastocysts.Journal of assisted reproduction and genetics · 2018Article
- Are blastocyst aneuploidy rates different between fertile and infertile populations?Journal of assisted reproduction and genetics · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAneuploidy is one of the major factors that result in low efficiency in human infertility treatment by in vitro fertilization (IVF). The development of DNA microarray technology allows for aneuploidy screening by analyzing all 23 pairs of chromosomes in human embryos. All chromosome screening for aneuploidy is more accurate than partial chromosome screening, as errors can occur in any chromosome. Currently, chromosome screening for aneuploidy is performed in developing embryos, mainly blastocysts. It has not been performed in arrested embryos and/or compared between developing embryos and arrested embryos from the same IVF cycle.
methodsThe present study was designed to examine all chromosomes in blastocysts and arrested embryos from the same cycle in patients of advanced maternal ages. Embryos were produced by routine IVF procedures. A total of 90 embryos (45 blastocysts and 45 arrested embryos) from 17 patients were biopsied and analyzed by the Agilent DNA array platform.
resultsIt was found that 50% of the embryos developed to blastocyst stage; however, only 15.6% of the embryos (both blastocyst and arrested) were euploid, and most (84.4%) of the embryos had chromosomal abnormalities. Further analysis indicated that 28.9% of blastocysts were euploid and 71.1% were aneuploid. By contrast, only one (2.2%) arrested embryo was euploid while others (97.8%) were aneuploid. The prevalence of multiple chromosomal abnormalities in the aneuploid embryos was also higher in the arrested embryos than in the blastocysts.
conclusionsThese results indicate that high proportions of human embryos from patients of advanced maternal age are aneuploid, and the arrested embryos are more likely to have abnormal chromosomes than developing embryos.
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