ArticleMetabolomics : Official journal of the Metabolomic Society2014
Associations between thyroid hormones and serum metabolite profiles in an euthyroid population.
Article in Metabolomics : Official journal of the Metabolomic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization.EBioMedicine · 2024Article
- Optimizing the Dutch newborn screening for congenital hypothyroidism by incorporating amino acids and acylcarnitines in a machine learning-based model.European thyroid journal · 2023Article
- Assessing the Influence of Propylthiouracil and Phenytoin on the Metabolomes of the Thyroid, Liver, and Plasma in Rats.Metabolites · 2023Article
- Significant dysregulation of lipid metabolism in patients with papillary thyroid carcinoma after thyroidectomy.Frontiers in endocrinology · 2023Article
- Metabolite biomarker discovery for human gastric cancer using dried blood spot mass spectrometry metabolomic approach.Scientific reports · 2022Article
- The metabolomics approach revealed a distinctive metabolomics pattern associated with hyperthyroidism treatment.Frontiers in endocrinology · 2022Article
- A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans.Thyroid : official journal of the American Thyroid Association · 2019Article
- Combination Thyroid Hormone Replacement; Knowns and Unknowns.Frontiers in endocrinology · 2019Review
- Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.Scientific reports · 2017Article
- Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.BMC medicine · 2017Article
- Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts.PloS one · 2017Article
- The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of Mice.European thyroid journal · 2015Article
- Urine Metabolomics by (1)H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans.European thyroid journal · 2015Article
Corrections and comments
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Authors and funding
19 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The aim was to characterise associations between circulating thyroid hormones-free thyroxine (FT4) and thyrotropin (TSH)-and the metabolite profiles in serum samples from participants of the German population-based KORA F4 study. Analyses were based on the metabolite profile of 1463 euthyroid subjects. In serum samples, obtained after overnight fasting (≥8), 151 different metabolites were quantified in a targeted approach including amino acids, acylcarnitines (ACs), and phosphatidylcholines (PCs). Associations between metabolites and thyroid hormone concentrations were analysed using adjusted linear regression models. To draw conclusions on thyroid hormone related pathways, intra-class metabolite ratios were additionally explored. We discovered 154 significant associations (Bonferroni
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