ArticlePediatric rheumatology online journal2014
Takayasu Arteritis in the pediatric population: a contemporary United States-based single center cohort.
Article in Pediatric rheumatology online journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma.Paediatric drugs · 2025Pooled it
- Real-World Biomarkers for Pediatric Takayasu Arteritis.International journal of molecular sciences · 2024Pooled it
- Wind of Change in the Treatment of Childhood-Onset Takayasu Arteritis: a Systematic Review.Current rheumatology reports · 2021Pooled it
- Clinical profile and long-term outcomes of pediatric-onset Takayasu's arteritis: data from a mexican national referral center.Pediatric rheumatology online journal · 2025Article
- Childhood-onset Takayasu arteritis: clinical presentation, challenges and disease course.Pediatric rheumatology online journal · 2025Article
- Diverse Vascular Manifestations of Takayasu Arteritis: Coronary Artery Stenosis and Aneurysmal Dilation in pediatric patients.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2025Article
- The Diagnostic Role of Skin Manifestations in Rheumatic Diseases in Children: A Critical Review of Paediatric Vasculitis.International journal of molecular sciences · 2024Review
- Cerebrovascular involvement in systemic childhood vasculitides.Clinical rheumatology · 2023Review
- An Update on Childhood-Onset Takayasu Arteritis.Frontiers in pediatrics · 2022Review
- Recent Advances in Pediatric Vasculitis.Rheumatic diseases clinics of North America · 2021Review
- Ultrasonography as a Diagnostic Support Tool for Childhood Takayasu Arteritis Referred to as Fever of Unknown Origin: Case Series and Literature Review.JMA journal · 2021Article
- Clinical course of 602 patients with Takayasu's arteritis: comparison between Childhood-onset versus adult onset disease.Rheumatology (Oxford, England) · 2021Article
- Poor physical activity levels and cardiorespiratory fitness among patients with childhood-onset takayasu arteritis in remission: a cross-sectional, multicenter study.Pediatric rheumatology online journal · 2021Article
- Non-specific aortoarteritis (NSAA) in children: a prospective observational study.BMJ paediatrics open · 2021Observational
- Morbidity and Mortality of Large-Vessel Vasculitides.Current rheumatology reports · 2020Review
- Takayasu Arteritis Presenting as Bilateral Ocular Ischemic Syndrome.Vascular specialist international · 2020Article
- The importance of FDG PET/CT in the diagnostic process of the middle aortic syndrome in a 15-year-old boy patient with suspected systemic vasculitis and final diagnosis of Williams-Beuren syndrome.Rheumatology international · 2020Review
- Childhood-onset Takayasu Arteritis.European journal of rheumatology · 2020Article
- Childhood-Onset Takayasu Arteritis (c-TA): Current and Future Drug Therapy.Paediatric drugs · 2019Review
- Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature review.Pediatric rheumatology online journal · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTakayasu Arteritis is an idiopathic, chronic, large vessel vasculitis involving the aorta and its primary branches. Few studies have been done in pediatric patients to date with the largest case series of US patients published in 2003 consisting of only 6 patients.
methodsA retrospective chart review was performed on all patients seen at Cleveland Clinic Children's up until 2012 who met EULAR/PRINTO/PRES classification criteria for childhood Takayasu Arteritis.
resultsTwenty-one patients with a mean follow up of 2.3 years were studied. Weight loss, fatigue, and anorexia were the most common presenting complaints. 57.1% of patients were hypertensive at first visit. The most common examintation finding was diminished pulses (61.9%), followed by bruits, and then murmurs. Thoracic aorta stenosis was the most common vascular abnormality. Seven of twenty-one patients responded well to methotrexate and prednisone alone. Ten of twenty-one patients required an additional medication for symptom and disease control (infliximab most commonly). About two-thirds of patients required at least one anti-hypertensive medication. Eight of the twenty-one patients required surgical intervention for severe disease refractory to medications (renal artery stenosis being the most common indication). Almost all patients reported symptomatic improvement after surgical intervention. Two of the eight patients required a second surgery for return of symptoms. Disease sequelae included arterial aneurysms, resolved heart failure, and hypertensive emergencies.
conclusionOur study emphasizes that constitutional symptoms coupled with objective findings of diminished pulses, bruits, and hypertension should raise clinical suspicion for Takayasu Arteritis in pediatric patients. Pharmacologic therapy alone can be successful in controlling disease progression, however surgery was successful in minimizing symptoms when medical therapies failed.
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