Evidence map›Paper›PMID 24954957›Full record

ArticleMolecular physics2013

Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls.

Janet E Lovett, Rachel J M Abbott, Pietro Roversi, Steven Johnson, Joseph J E Caesar, Marianna Doria, Gunnar Jeschke, Christiane R Timmel, Susan M Lea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Protein Modeling with DEER Spectroscopy.Annual review of biophysics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Janet E LovettSir William Dunn School of Pathology, University of Oxford, Oxford, UK ; EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK.
Rachel J M AbbottSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Pietro RoversiSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Steven JohnsonSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Joseph J E CaesarSir William Dunn School of Pathology, University of Oxford, Oxford, UK ; Centre for Advanced Electron Spin Resonance, Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK.
Marianna DoriaSir William Dunn School of Pathology, University of Oxford, Oxford, UK ; Centre for Advanced Electron Spin Resonance, Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK.
Gunnar JeschkeLaboratory for Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Christiane R TimmelCentre for Advanced Electron Spin Resonance, Inorganic Chemistry Laboratory, University of Oxford, Oxford, UK.
Susan M LeaSir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The electron paramagnetic resonance technique of double electron-electron resonance (DEER) was used to measure nanometre-scale distances between nitroxide spin labels attached to the complement regulatory protein CD55 (also known as decay accelerating factor) and the von Willebrand factor A (vWF-A) domain of factor B. Following a thorough assessment of the quality of the data, distances obtained from good-quality measurements are compared to predicted distances from a previously hypothesised model for the complex and are found to be incompatible. The success of using these distances as restraints in multi-body docking routines is presented critically.

Indexed as

CD55decay accelerationDEERdistance restraintsvWF-A

Identifiers

PMID24954957
PMCPMC4056885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.