Evidence map›Paper›PMID 24954822›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2014

Randomized efficacy trial of two psychotherapies for depression in youth with inflammatory bowel disease.

Eva Szigethy, Simona I Bujoreanu, Ada O Youk, John Weisz, David Benhayon, Diane Fairclough, Peter Ducharme, Joseph Gonzalez-Heydrich, David Keljo, Arvind Srinath and 5 more

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00534911 (Reducing Depressive Symptoms in Physically Ill Youth), which is not on this map. Cited by 45 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 8 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00534911 nacompletednot on this map

Reducing Depressive Symptoms in Physically Ill Youth

TypeinterventionalSponsorUniversity of PittsburghRan2007 to 2019Enrolled76ConditionsInflammatory Bowel Disease, DepressionArmsCognitive Behavioral Therapy, Supportive Non-directive Therapy (SNDT)
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 8 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
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  7. Guideline
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
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  17. Review
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  20. Psychological Treatments for Depression in Adolescents: More Than Three Decades Later.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Eva SzigethyUniversity of Pittsburgh. Electronic address: szigethye@upmc.edu.
Simona I BujoreanuBoston Children's Hospital.
Ada O YoukUniversity of Pittsburgh.
John WeiszHarvard University.
David BenhayonUniversity of Pittsburgh.
Diane FaircloughColorado School of Public Health.
Peter DucharmeBoston Children's Hospital.
Joseph Gonzalez-HeydrichBoston Children's Hospital.
David KeljoUniversity of Pittsburgh.
Arvind SrinathUniversity of Pittsburgh.
Athos BousvarosBoston Children's Hospital.
Margaret KirshnerUniversity of Pittsburgh.
Melissa NewaraUniversity of Pittsburgh.
David KupferUniversity of Pittsburgh.
David R DeMasoBoston Children's Hospital.
University of Pittsburgh · USBoston Children's Museum · USBoston Children's Hospital · USColorado School of Public Health · USHarvard University Press · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Reducing Depressive Symptoms in Physically Ill YouthR01MH077770 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEMASO, DAVID R, SZIGETHY, EVA M · 2008 to 2012
$3.2M
NCATS NIH HHS UL1 TR000005NIMH NIH HHS R01 MH077770
6 · The paper itself

Abstract

objectivePediatric inflammatory bowel disease (IBD) is associated with high rates of depression. This study compared the efficacy of cognitive behavioral therapy (CBT) to supportive nondirective therapy (SNDT) in treating youth with comorbid IBD and depression.

methodYouth (51% female and 49% male; age 9-17 years, mean age 14.3 years) with depression and Crohn's disease (n = 161) or ulcerative colitis (n = 56) were randomly assigned to a 3-month course of CBT or SNDT. The primary outcome was comparative reduction in depressive symptom severity; secondary outcomes were depression remission, increase in depression response, and improved health-related adjustment and IBD activity.

resultsA total of 178 participants (82%) completed the 3-month intervention. Both psychotherapies resulted in significant reductions in total Children's Depression Rating Scale Revised score (37.3% for CBT and 31.9% for SNDT), but the difference between the 2 treatments was not significant (p = .16). There were large pre-post effect sizes for each treatment (d = 1.31 for CBT and d = 1.30 for SNDT). More than 65% of youth had a complete remission of depression at 3 months, with no difference between CBT and SNDT (67.8% and 63.2%, respectively). Compared to SNDT, CBT was associated with a greater reduction in IBD activity (p = .04) but no greater improvement on the Clinical Global Assessment Scale (p = .06) and health-related quality of life (IMPACT-III scale) (p = .07).

conclusionThis is the first randomized controlled study to suggest improvements in depression severity, global functioning, quality of life, and disease activity in a physically ill pediatric cohort treated with psychotherapy. Clinical trial registration information-Reducing Depressive Symptoms in Physically Ill Youth; http://clinical trials.gov; NCT00534911.

Indexed as

AdolescentChildCognitive Behavioral TherapyDepressionFemaleHumansInflammatory Bowel DiseasesMalePsychotherapyTreatment Outcomedepressioninflammatory bowel diseasephysical illnesspsychotherapyquality of life

Identifiers

PMID24954822
PMCPMC4104185
OpenAlexW2058706903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.