ArticleJournal of neuroscience methods2015
Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Brain augmentation and neuroscience technologies: current applications, challenges, ethics and future prospects.Frontiers in systems neuroscience · 2022Review
- Neurotechnologies for Human Cognitive Augmentation: Current State of the Art and Future Prospects.Frontiers in human neuroscience · 2019Review
- Human Brain/Cloud Interface.Frontiers in neuroscience · 2019Article
- Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
- Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism.Neuroscience letters · 2015Article
- Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.Frontiers in systems neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The mammalian prefrontal cortex known as the seat of high brain functions uses a six layer distribution of minicolumnar neurons to coordinate the integration of sensory information and the selection of relevant signals for goal driven behavior. To reveal the complex functionality of these columnar microcircuits we employed simultaneous recordings with several configurations of biomorphic microelectrode arrays (MEAs) within cortical layers in adjacent minicolumns, in four nohuman primates (NHPs) performing a delayed match-to-sample (DMS) visual discrimination task. We examined: (1) the functionality of inter-laminar, and inter-columnar interactions between pairs of cells in the same or different minicolumns by use of normalized cross-correlation histograms (CCH), (2) the modulation of glutamate concentration in layer 2/3, and (3) the potential interactions within these microcircuits. The results demonstrate that neurons in both infra-granular and supra-granular layers interact through inter-laminar loops, as well as through intra-laminar to produce behavioral response signals. These results provide new insights into the manner in which prefrontal cortical microcircuitry integrates sensory stimuli used to provide behaviorally relevant signals that may be implemented in brain computer/machine interfaces (BCI/BMIs) during performance of the task.
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Registered trials
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