ArticleImmunogenetics2014
Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis.
Article in Immunogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity.BMC medical genomics · 2023Article
- The New Version of the ANDDigest Tool with Improved AI-Based Short Names Recognition.International journal of molecular sciences · 2022Article
- Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks.International journal of molecular sciences · 2021Article
- Asthma and pulmonary tuberculosis: misdiagnosis or coexistence.Respirology case reports · 2021Article
- Bioinformatic Reconstruction and Analysis of Gene Networks Related to Glucose Variability in Diabetes and Its Complications.International journal of molecular sciences · 2020Article
- ANDDigest: a new web-based module of ANDSystem for the search of knowledge in the scientific literature.BMC bioinformatics · 2020Article
- Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem.BMC medical genomics · 2019Article
- Article
- Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks.BMC medical genomics · 2018Article
- FunGeneNet: a web tool to estimate enrichment of functional interactions in experimental gene sets.BMC genomics · 2018Article
- Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain.BMC genomics · 2015Article
- ANDSystem: an Associative Network Discovery System for automated literature mining in the field of biology.BMC systems biology · 2015Article
- Molecular association of pathogenetic contributors to pre-eclampsia (pre-eclampsia associome).BMC systems biology · 2015Article
- Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Co-existence of bronchial asthma (BA) and tuberculosis (TB) is extremely uncommon (dystropic). We assume that this is caused by the interplay between genes involved into specific pathophysiological pathways that arrest simultaneous manifestation of BA and TB. Identification of common and specific genes may be important to determine the molecular genetic mechanisms leading to rare co-occurrence of these diseases and may contribute to the identification of susceptibility genes for each of these dystropic diseases. To address the issue, we propose a new methodological strategy that is based on reconstruction of associative networks that represent molecular relationships between proteins/genes associated with BA and TB, thus facilitating a better understanding of the biological context of antagonistic relationships between the diseases. The results of our study revealed a number of proteins/genes important for the development of both BA and TB.
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