ArticleScientific reports2014
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis.Scientific reports · 2015Pooled it
- The Expression Pattern and Clinical Significance of Lysyl Oxidase Family in Gliomas.Doklady. Biochemistry and biophysics · 2023Article
- Lipocalin 2 receptors: facts, fictions, and myths.Frontiers in immunology · 2023Review
- Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer.Cell & bioscience · 2022Article
- Identification of Novel Choroidal Neovascularization-Related Genes Using Laplacian Heat Diffusion Algorithm.BioMed research international · 2021Article
- The analyses of SRCR genes based on protein-protein interaction network in esophageal squamous cell carcinoma.American journal of translational research · 2019Article
- Integrative network analyses of wilt transcriptome in chickpea reveal genotype dependent regulatory hubs in immunity and susceptibility.Scientific reports · 2018Article
- STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.Journal of immunology research · 2018Article
- Network-Based Differential Analysis to Identify Molecular Features of Tumorigenesis for Esophageal Squamous Carcinoma.Molecules (Basel, Switzerland) · 2018Article
- Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinoma.FEBS open bio · 2017Article
- Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases.Oncotarget · 2016Article
- Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy.Allergy · 2016Review
- A powerful score-based statistical test for group difference in weighted biological networks.BMC bioinformatics · 2016Article
- Network analysis reveals potential markers for pediatric adrenocortical carcinoma.OncoTargets and therapy · 2016Article
- A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.Scientific reports · 2015Article
- Functional analysis of the mRNA profile of neutrophil gelatinase‑associated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools.Molecular medicine reports · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LCN2 (lipocalin 2) is a member of the lipocalin family of proteins that transport small, hydrophobic ligands. LCN2 is elevated in various cancers including esophageal squamous cell carcinoma (ESCC). In this study, LCN2 was overexpressed in the EC109 ESCC cell line and we applied integrated analyses of the gene expression data to identify protein-protein interactions (PPI) network to enhance our understanding of the role of LCN2 in ESCC. Through further mining of PPI sub-networks, hundreds of differentially expressed genes (DEGs) were identified to interact with thousands of other proteins. Subcellular localization analyses found the DEGs and their directly or indirectly interacting proteins distributed in multiple layers, which was applied to analyze the possible paths between two DEGs. Gene Ontology annotation generated a functional annotation map and found hundreds of significant terms, especially those associated with the known and potential roles of LCN2 protein. The algorithm of Random Walk with Restart was applied to prioritize the DEGs and identified several cancer-related DEGs ranked closest to LCN2 protein. These analyses based on PPI network have greatly expanded our understanding of the mRNA expression profile of LCN2 overexpression for future examination of the roles and mechanisms of LCN2.
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