Evidence map›Paper›PMID 24954616›Full record

ArticleStructure (London, England : 1993)2014

Structure-based characterization of multiprotein complexes.

Markus Wiederstein, Markus Gruber, Karl Frank, Francisco Melo, Manfred J Sippl

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  6. Cellular homologs of the double jelly-roll major capsid proteins clarify the origins of an ancient virus kingdom.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  9. Unlimited Cooperativity ofFrontiers in microbiology · 2021
    Article
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  17. Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Markus WiedersteinDivision of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria. Electronic address: markII@came.sbg.ac.at.
Markus GruberDivision of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
Karl FrankDivision of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
Francisco MeloDepartamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8320000 Santiago, Chile; Molecular Bioinformatics Laboratory, Millennium Institute on Immunology and Immunotherapy, 8320000 Santiago, Chile.
Manfred J SipplDivision of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.

Funding

Austrian Science Fund FWF P 21294
6 · The paper itself

Abstract

Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.

Indexed as

Protein Structure, QuaternaryAlgorithmsComputational BiologyDatabases, ProteinInformation Storage and RetrievalInternetModels, MolecularMultiprotein ComplexesProtein ConformationReproducibility of ResultsMultiprotein Complexes

Identifiers

PMID24954616
PMCPMC4087271

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.