ArticleBMC medical genomics2014
Selection of competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for patients undergoing preimplantation genetic screening: a prospective study with sibling oocytes.
Article in BMC medical genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02657811 (Time-Lapse Incubation for Embryo Culture - The Impact of Morphokinetics and Environmental Stability on Reproductive Outcomes), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time-Lapse Incubation for Embryo Culture - The Impact of Morphokinetics and Environmental Stability on Reproductive Outcomes
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2019Pooled it
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2018Pooled it
- Trial
- Randomized comparison of next-generation sequencing and array comparative genomic hybridization for preimplantation genetic screening: a pilot study.BMC medical genomics · 2015Trial
- Effect of re-biopsy and re-vitrification on clinical outcomes in preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Non-Invasive Preimplantation Genetic Testing.Genes · 2025Review
- Article
- Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status.Journal of assisted reproduction and genetics · 2023Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- End-to-end deep learning for recognition of ploidy status using time-lapse videos.Journal of assisted reproduction and genetics · 2021Article
- Single-embryo transfer: a key strategy to reduce the risk for multiple pregnancy in assisted human reproduction.Advances in laboratory medicine · 2021Review
- Time-lapse technology for embryo culture and selection.Upsala journal of medical sciences · 2020Review
- Blastocyst contractions are strongly related with aneuploidy, lower implantation rates, and slow-cleaving embryos: a time lapse study.JBRA assisted reproduction · 2020Article
- The KidscoreJBRA assisted reproduction · 2020Article
- Can trophectoderm RNA analysis predict human blastocyst competency?Systems biology in reproductive medicine · 2019Article
- Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.Journal of assisted reproduction and genetics · 2019Article
- Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.Journal of assisted reproduction and genetics · 2019Article
- The Effect of Advanced Maternal Age on Embryo Morphokinetics.Frontiers in endocrinology · 2019Article
- Assessing equine embryo developmental competency by time-lapse image analysis.Reproduction, fertility, and development · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent advances in time-lapse monitoring in IVF treatment have provided new morphokinetic markers for embryonic competence. However, there is still very limited information about the relationship between morphokinetic parameters, chromosomal compositions and implantation potential. Accordingly, this study aimed at investigating the effects of selecting competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing on pregnancy and implantation outcomes for patients undergoing preimplantation genetic screening (PGS).
methodsA total of 1163 metaphase II (MII) oocytes were retrieved from 138 PGS patients at a mean age of 36.6 ± 2.4 years. These sibling MII oocytes were then randomized into two groups after ICSI: 1) Group A, oocytes (n = 582) were cultured in the time-lapse system and 2) Group B, oocytes (n = 581) were cultured in the conventional incubator. For both groups, whole genomic amplification and array CGH testing were performed after trophectoderm biopsy on day 5. One to two euploid blastocysts within the most predictive morphokinetic parameters (Group A) or with the best morphological grade available (Group B) were selected for transfer to individual patients on day 6. Ongoing pregnancy and implantation rates were compared between the two groups.
resultsThere were significant differences in clinical pregnancy rates between Group A and Group B (71.1% vs. 45.9%, respectively, p = 0.037). The observed implantation rate per embryo transfer significantly increased in Group A compared to Group B (66.2% vs. 42.4%, respectively, p = 0.011). Moreover, a significant increase in ongoing pregnancy rates was also observed in Group A compared to Group B (68.9% vs. 40.5%. respectively, p = 0.019). However, there was no significant difference in miscarriage rate between the time-lapse system and the conventional incubator (3.1% vs. 11.8%, respectively, p = 0.273).
conclusionsThis is the first prospective investigation using sibling oocytes to evaluate the efficiency of selecting competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for PGS patients. Our data clearly demonstrate that the combination of these two advanced technologies to select competent blastocysts for transfer results in improved implantation and ongoing pregnancy rates for PGS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.