SynthesisActa orthopaedica2014
No clinical benefit of gender-specific total knee arthroplasty.
Synthesis in Acta orthopaedica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- No significant difference in early clinical outcomes of custom versus off-the-shelf total knee arthroplasty: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- What Differences in Morphologic Features of the Knee Exist Among Patients of Various Races? A Systematic Review.Clinical orthopaedics and related research · 2017Pooled it
- New mobile-bearing TKA with unique ball and socket post-cam mechanism offers similar function and stability with better prosthesis fit and gap balancing compared to an established fixed-bearing prosthesis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Trial
- Implications of Size and Gender for Implant Fit and Coverage in Total Ankle Replacement.Foot & ankle orthopaedics · 2026Article
- Virtual cutting-based morphological differences in osteoarthritic and healthy knees: Implications for total knee arthroplasty prosthesis design.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Observational
- Sex and Gender in Orthopaedic Research: How Do We Continue to Move the Needle?The Journal of bone and joint surgery. American volume · 2024Article
- Bilateral simultaneous hip and knee replacement: an epidemiological nationwide study from 2001 to 2016.BMC surgery · 2024Article
- Patterns of Change Over Time in Knee Bone Shape Are Associated with Sex.Clinical orthopaedics and related research · 2020Observational
- No clinical benefit from gender-specific total knee replacement implants: a systematic review.SICOT-J · 2020Article
- Sexual and ethnic polymorphism render prosthetic overhang and under-coverage inevitable using off-the shelf TKA implants.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Mediolateral femoral component position in TKA significantly alters patella shift and femoral roll-back.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Does knee awareness differ between different knee arthroplasty prostheses? A matched, case-control, cross-sectional study.BMC musculoskeletal disorders · 2016Article
- Are Korean Patients Different from Other Ethnic Groups in Total Knee Arthroplasty?Knee surgery & related research · 2015Review
- No clinical benefit of gender-specific total knee arthroplasty: A systematic review and meta-analysis of 6 randomized controlled trials.Acta orthopaedica · 2015Article
- Early outcomes of patient-specific posterior stabilized total knee arthroplasty implants.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is no consensus regarding the clinical relevance of gender-specific prostheses in total knee arthroplasty (TKA). We summarize the current best evidence in a comparison of clinical and radiographic outcomes between gender-specific prostheses and standard unisex prostheses in female patients.
methodsWe used the PubMed, Embase, Cochrane, Science Citation Index, and Scopus databases. We included randomized controlled trials published up to January 2013 that compared gender-specific prostheses with standard unisex prostheses in female patients who underwent primary TKAs.
results6 trials involving 423 patients with 846 knee joints met the inclusion criteria. No statistically significant differences were observed between the 2 designs regarding pain, range of motion (ROM), knee scores, satisfaction, preference, complications, and radiographic results. The gender-specific design (Gender Solutions; Zimmer Inc, Warsaw, Indiana) reduced the prevalence of overhang. However, it had less overall coverage of the femoral condyles compared to the unisex group. In fact, the femoral prosthesis in the standard unisex group matched better than that in the gender-specific group.
interpretationGender-specific prostheses do not appear to confer any benefit in terms of clinician- and patient-reported outcomes for the female knee.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.