ArticleActa psychiatrica Scandinavica2015
Substance use in adulthood following adolescent self-harm: a population-based cohort study.
Article in Acta psychiatrica Scandinavica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343039 (Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents), which is not on this map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Biomarkers and New Technologies to Reduce Self-Injury and Substance Abuse Risk Among Highly Vulnerable Adolescents
Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- Mediation effects that emulate a target randomised trial: Simulation-based evaluation of ill-defined interventions on multiple mediators.Statistical methods in medical research · 2021Trial
- Predicting adult mental health from non-suicidal self-injury in adolescence: a prospective study spanning 2007-2023.European child & adolescent psychiatry · 2025Article
- Historical Nonsuicidal Self-Injury and Current Coping Strategies: The Role of Emotion Regulation.Personality and mental health · 2025Article
- Characteristics of Self-Harm in an Emergency Situation Among Youth: A Longitudinal Five- Year Cohort Study.Research on child and adolescent psychopathology · 2025Article
- Substance Use, Internet Risk Behavior, and Depressive Symptoms as Predictors of Self-harm Thoughts in Adolescents: Insights from the 2019 ESPAD Survey in Croatia.Child psychiatry and human development · 2025Article
- An early economic evaluation of Kooth, a web-based mental health platform for children and young people with emerging mental health needs.Internet interventions · 2024Article
- Teen Pregnancy and Risk of Premature Mortality.JAMA network open · 2024Article
- Mental ill-health and substance use among sexuality diverse adolescents: The critical role of school climate and teacher self-efficacy.The Australian and New Zealand journal of psychiatry · 2024Article
- Self-harm in adolescence and risk of crash: a 13-year cohort study of novice drivers in New South Wales, Australia.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2023Article
- Life Chart of Substance Use Career: A Clinical Profile Study from Turkey.Psychiatry and clinical psychopharmacology · 2023Article
- Autism and self-harm: A population-based and discordant sibling study of young individuals.Acta psychiatrica Scandinavica · 2022Article
- Cognitive and emotional factors associated with the desire to cease non-suicidal self-injury.Journal of clinical psychology · 2022Article
- The gendered relationship between illicit substance use and self-harm in university students.Social psychiatry and psychiatric epidemiology · 2022Article
- Utilization and Acceptability of Formal and Informal Support for Adolescents Following Self-Harm Before and During the First COVID-19 Lockdown: Results From a Large-Scale English Schools Survey.Frontiers in psychiatry · 2022Article
- What happens to young adults who have engaged in self-injurious behavior as adolescents? A 10-year follow-up.European child & adolescent psychiatry · 2021Article
- Development of a Self-Harm Monitoring System for Victoria.International journal of environmental research and public health · 2020Article
- Comparison of suicide risk and other outcomes among boys and girls who self-harm.European child & adolescent psychiatry · 2020Article
- PTSD's risky behavior criterion: Associated risky and unhealthy behaviors and psychiatric correlates in a nationally representative sample.Journal of anxiety disorders · 2020Article
- Before the damage is done: Early childhood hyperactivity difficulties in adolescents with deliberate self-harm - findings from the DALSC cohort.Scandinavian journal of child and adolescent psychiatry and psychology · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether adolescents who self-harm are at increased risk of heavy and dependent substance use in adulthood.
methodFifteen-year prospective cohort study of a random sample of 1943 adolescents recruited from secondary schools across the state of Victoria, Australia. Data pertaining to self-harm and substance use was obtained at seven waves of follow-up, from mean age 15.9 years to mean age 29.1 years.
resultsSubstance use and self-harm were strongly associated during the adolescent years (odds ratio (OR): 3.3, 95% CI 2.1-5.0). Moreover, adolescent self-harmers were at increased risk of substance use and dependence syndromes in young adulthood. Self-harm predicted a four-fold increase in the odds of multiple dependence syndromes (sex- and wave-adjusted OR: 4.2, 95% CI: 2.7-6.6). Adjustment for adolescent anxiety/depression attenuated but did not eliminate most associations. Adolescent substance use confounded all associations, with the exception of multiple dependence syndromes, which remained robustly associated with adolescent self-harm (fully adjusted odds ratio: 2.0, 95% CI: 1.2-3.2).
conclusionAdolescent self-harm is an independent risk factor for multiple dependence syndromes in adulthood. This level of substance misuse is likely to contribute substantially to the premature mortality and disease burden experienced by individuals who self-harm.
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